Tbio LYVE1 Lymphatic vessel endothelial hyaluronic acid receptor 1

Protein Summary

Description

Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y5Y7
• Q8TC18
• Q9UNF4
• LYVE-1

Gene Name

• LYVE1

Ensembl ID

• ENST00000256178
• ENSP00000256178
• ENSG00000133800

Symbol

• CRSBP1
• HAR
• XLKD1
• HAR
• XLKD1
• LYVE-1
• CRSBP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.92
gene perturbation	0.75
PubMedID	0.67
kinase perturbation	0.66
biological term	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 638.1   (req: < 5)

Gene RIFs: 52   (req: <= 3)

Antibodies: 767   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 638.1   (req: >= 5)

Gene RIFs: 52   (req: > 3)

Antibodies: 767   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0