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Tchem
ST14
Suppressor of tumorigenicity 14 protein

Protein Summary
Description
Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing. The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278742
  • ENSP00000278742
  • ENSG00000149418

Symbol
  • PRSS14
  • SNC19
  • TADG15
  • HAI
  • MTSP1
  • SNC19
  • ARCI11
  • MT-SP1
  • PRSS14
  • TADG15
  • TMPRSS14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
PubMedID
0.85
biological term
0.82
virus perturbation
0.76
kinase perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 388.45   (req: < 5)
Gene RIFs: 104   (req: <= 3)
Antibodies: 393   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 388.45   (req: >= 5)
Gene RIFs: 104   (req: > 3)
Antibodies: 393   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 220
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HIV-1 infection
1
1
1
64.6
viral load
1
1
1
64.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HIV-1 infection
1
64.6
viral load
1
64.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
suppression of tumorigenicity 14
VGNC:3057
100188950
Macaque
suppression of tumorigenicity 14
718848
Mouse
MGI:1338881
19143
Rat
RGD:69288
114093
Dog
suppression of tumorigenicity 14
VGNC:46848
489278
Species
Name
OMA
EggNOG
Inparanoid
Chimp
suppression of tumorigenicity 14
Macaque
suppression of tumorigenicity 14
Mouse
Rat
Dog
suppression of tumorigenicity 14
Protein Structure (22 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y5Y6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 22
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Protein-Protein Interactions (37)
1 – 10 of 37
SPINT1
Tbio
Family: Enzyme
Novelty: 0.00930324
Score: 0.996
Data Source: STRINGDB
FLG
Tbio
Novelty: 0.00072986
Score: 0.961
Data Source: Reactome,STRINGDB
KLK5
Tchem
Family: Enzyme
Novelty: 0.00835407
Score: 0.917
Data Source: Reactome,STRINGDB
SPINT2
Tbio
Family: Enzyme
Novelty: 0.0046602
Score: 0.886
Data Source: STRINGDB
SPINK5
Tbio
Family: Enzyme
Novelty: 0.00451563
Score: 0.752
Data Source: STRINGDB
CDCP1
Tbio
Novelty: 0.01385067
Score: 0.729
Data Source: STRINGDB
ST13
Tbio
Novelty: 0.00908434
Score: 0.724
Data Source: STRINGDB
F8
Tbio
Novelty: 0.0002287
Score: 0.713
Data Source: STRINGDB
F2RL1
Tchem
Family: GPCR
Novelty: 0.00445327
Score: 0.669
Data Source: STRINGDB
CLDN7
Tbio
Novelty: 0.00722366
Score: 0.583
Data Source: STRINGDB
Publication Statistics
PubMed Score  388.45

PubMed score by year
PubTator Score  117.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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