Tbio PEX16 Peroxisomal membrane protein PEX16

Protein Summary

Description

Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3. The protein encoded by this gene is an integral peroxisomal membrane protein. An inactivating nonsense mutation localized to this gene was observed in a patient with Zellweger syndrome of the complementation group CGD/CG9. Expression of this gene product morphologically and biochemically restores the formation of new peroxisomes, suggesting a role in peroxisome organization and biogenesis. Alternative splicing has been observed for this gene and two variants have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y5Y5
• Q9BWB9

Gene Name

• PEX16

Ensembl ID

• ENST00000241041
• ENSP00000241041
• ENSG00000121680
• ENST00000378750
• ENSP00000368024

Symbol

• PBD8A
• PBD8B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.88
histone modification site profile	0.76
cellular component	0.74
disease perturbation	0.74
kinase perturbation	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.28   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 113   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.28   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (83)

Explore Interacting Targets

1 – 10 of 83

• See Interactions on String-DB

PEX19

Tbio

Novelty:  0.00605342

p_int:  0.997510162

p_ni:  0.001804541

p_wrong:  0.000685297

Score:  0.958

Data Source:  BioPlex,Reactome,STRINGDB

GLMP

Tdark

Novelty:  0.10163099

p_int:  0.993664934

p_ni:  0.006334883

p_wrong:  1.83e-7

Data Source:  BioPlex

APLNR

Tchem

Family:  GPCR

Novelty:  0.00224203

p_int:  0.99065033

p_ni:  0.008848473

p_wrong:  0.000501197

Data Source:  BioPlex

SLC39A12

Tbio

Family:  Transporter

Novelty:  0.09127395

p_int:  0.980423148

p_ni:  0.018286217

p_wrong:  0.001290634

Data Source:  BioPlex

FAM234B

Tdark

Novelty:  1.53957047

p_int:  0.973921623

p_ni:  0.025779358

p_wrong:  0.000299019

Data Source:  BioPlex

SLC2A12

Tbio

Family:  Transporter

Novelty:  0.01455533

p_int:  0.973921623

p_ni:  0.025779358

p_wrong:  0.000299019

Data Source:  BioPlex

SCN3B

Tbio

Family:  IC

Novelty:  0.0438123

p_int:  0.964622484

p_ni:  0.035377477

p_wrong:  3.9e-8

Data Source:  BioPlex

CD79A

Tbio

Novelty:  0.00118942

p_int:  0.956343398

p_ni:  0.001708005

p_wrong:  0.041948597

Data Source:  BioPlex

C3AR1

Tchem

Family:  GPCR

Novelty:  0.00527301

p_int:  0.912487749

p_ni:  0.087502072

p_wrong:  0.000010179

Data Source:  BioPlex

MICB

Tbio

Novelty:  0.00364639

p_int:  0.876091182

p_ni:  0.003246059

p_wrong:  0.120662759

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (2)

KEGG (1)

Class I peroxisomal membrane protein import (R-HSA-9603798)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class I peroxisomal membrane protein import	20 targets	R-HSA-9603798
Reactome	Protein localization	165 targets	R-HSA-9609507

Name	Explore in Pharos	Explore in Source
Class I peroxisomal membrane protein import	20 targets	R-HSA-9603798
Protein localization	165 targets	R-HSA-9609507

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (1)

Components (6)

Processes (8)

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GO Term	Evidence	Assigned by
protein C-terminus binding	Inferred from Physical Interaction (IPI)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (13)

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1 – 5 of 13

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glucose measurement	EFO_0004468	2	2	2		91.9
high density lipoprotein cholesterol measurement	EFO_0004612	3	2	3		87.5
fasting blood glucose measurement	EFO_0004465	6	1	6		77.9
type II diabetes mellitus	EFO_0001360	3	3	2	1	71.4
body mass index	EFO_0004340	1	1	1		63.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 13

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glucose measurement	EFO_0004468	2		91.9
high density lipoprotein cholesterol measurement	EFO_0004612	3		87.5
fasting blood glucose measurement	EFO_0004465	6		77.9
type II diabetes mellitus	EFO_0001360	2	1	71.4
body mass index	EFO_0004340	1		63.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Disease mutation
Membrane
Peroxisome
Peroxisome biogenesis
Peroxisome biogenesis disorder
Polymorphism
Reference proteome
Transmembrane

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist circumference
body height
body mass index
fasting blood glucose measurement
glucose measurement
high density lipoprotein cholesterol measurement
mathematical ability
mean corpuscular hemoglobin concentration
sex hormone-binding globulin measurement
smoking status measurement

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	peroxisomal biogenesis factor 16	VGNC:1091	451150
Macaque	peroxisomal biogenesis factor 16		714904
Mouse	peroxisomal biogenesis factor 16	MGI:1338829	18633
Rat	peroxisomal biogenesis factor 16	RGD:1311372	311203
Dog	peroxisomal biogenesis factor 16	VGNC:44431	483639

Species	Name	OMA	EggNOG	Inparanoid
Chimp	peroxisomal biogenesis factor 16
Macaque	peroxisomal biogenesis factor 16
Mouse	peroxisomal biogenesis factor 16
Rat	peroxisomal biogenesis factor 16
Dog	peroxisomal biogenesis factor 16

Publication Statistics

PubMed Score 37.28

PubMed score by year

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PubTator Score 24.37

PubTator score by year

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Related Publications

Text Mined References (27)

GeneRif Annotations (6)

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PMID	Year	Title