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Tchem
PTGDR2
Prostaglandin D2 receptor 2

Protein Summary
Description
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332539
  • ENSP00000332812
  • ENSG00000183134

Symbol
  • CRTH2
  • DL1R
  • GPR44
  • DP2
  • DL1R
  • CD294
  • CRTH2
  • GPR44
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.72
biological term
0.62
molecular function
0.6
phenotype
0.57
cell line
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 353.73   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 598   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 353.73   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 598   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2059
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cathepsin L1 measurement
1
1
1
77.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cathepsin L1 measurement
1
77.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prostaglandin D2 receptor 2
VGNC:11680
466622
Macaque
prostaglandin D2 receptor 2
695853
Mouse
MGI:1330275
14764
Rat
RGD:1311986
309212
Dog
prostaglandin D2 receptor 2
VGNC:45141
483805
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prostaglandin D2 receptor 2
Macaque
prostaglandin D2 receptor 2
Mouse
Rat
Dog
prostaglandin D2 receptor 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y5Y4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Eicosanoid ligand-binding receptors
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Eicosanoid ligand-binding receptors
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (277)
1 – 10 of 277
GNAI1
Tbio
Novelty:  0.0488971
Score:  0.95
Data Source:  STRINGDB
CCL27
Tbio
Novelty:  0.00163457
Score:  0.95
Data Source:  STRINGDB
PTGER3
Tclin
Family:  GPCR
Novelty:  0.0012681
Score:  0.949
Data Source:  STRINGDB
CCL5
Tchem
Novelty:  0.00032607
Score:  0.926
Data Source:  STRINGDB
CXCL8
Tchem
Novelty:  0.00005958
Score:  0.922
Data Source:  STRINGDB
PMCH
Tbio
Novelty:  0.00600873
Score:  0.922
Data Source:  STRINGDB
CCR3
Tchem
Family:  GPCR
Novelty:  0.00197059
Score:  0.92
Data Source:  STRINGDB
CXCR3
Tchem
Family:  GPCR
Novelty:  0.00100538
Score:  0.917
Data Source:  STRINGDB
CCL1
Tbio
Novelty:  0.00379626
Score:  0.916
Data Source:  STRINGDB
CCL21
Tbio
Novelty:  0.00130736
Score:  0.915
Data Source:  STRINGDB
Publication Statistics
PubMed Score  353.73

PubMed score by year
PubTator Score  194.38

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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