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Tbio
FLVCR1
Feline leukemia virus subgroup C receptor-related protein 1

Protein Summary
Description
Isoform 1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. Causes susceptibility to FeLV-C in vitro. Isoform 2: Heme transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation. This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366971
  • ENSP00000355938
  • ENSG00000162769

Symbol
  • FLVCR
  • PCA
  • AXPC1
  • FLVCR
  • PCARP
  • MFSD7B
  • SLC49A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.78
virus perturbation
0.72
kinase perturbation
0.71
transcription factor binding site profile
0.69
microRNA
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.68   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.68   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
KIR2DL1
Tbio
Novelty:  0.00523657
p_int:  0.999885941
p_ni:  0.000114059
Data Source:  BioPlex
NT5E
Tchem
Family:  Enzyme
Novelty:  0.00083237
p_int:  0.999532191
p_ni:  0.000467809
Data Source:  BioPlex
SLC20A1
Tbio
Family:  Transporter
Novelty:  0.01123373
p_int:  0.999225957
p_ni:  0.000774043
Score:  0.357
Data Source:  BioPlex,STRINGDB
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.997775022
p_ni:  0.002224978
Data Source:  BioPlex
MICA
Tbio
Novelty:  0.03965901
p_int:  0.997569565
p_ni:  0.002430435
Score:  0.516
Data Source:  BioPlex,STRINGDB
LYPD3
Tbio
Novelty:  0.03248533
p_int:  0.988003273
p_ni:  0.011996684
p_wrong:  4.3e-8
Data Source:  BioPlex
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.985142854
p_ni:  0.014857146
Data Source:  BioPlex
XKRX
Tdark
Novelty:  0.35938148
p_int:  0.982760105
p_ni:  0.017239895
Score:  0.167
Data Source:  BioPlex,STRINGDB
SLC7A1
Tbio
Family:  Transporter
Novelty:  0.00197313
p_int:  0.982486384
p_ni:  0.017513612
p_wrong:  4e-9
Score:  0.204
Data Source:  BioPlex,STRINGDB
KEL
Tbio
Family:  Enzyme
Novelty:  0.00264913
p_int:  0.979615569
p_ni:  0.020384431
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Iron uptake and transport (R-HSA-917937)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Iron uptake and transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Iron uptake and transport
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
2
2
81.4
hematocrit
2
2
2
74
reticulocyte count
1
1
1
44.2
childhood onset asthma
1
1
0
1.1
40.7
self reported educational attainment
1
1
1
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
81.4
hematocrit
2
74
reticulocyte count
1
44.2
childhood onset asthma
0
1.1
40.7
self reported educational attainment
1
37.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
feline leukemia virus subgroup C cellular receptor 1
VGNC:1242
457724
Macaque
feline leukemia virus subgroup C cellular receptor 1
710008
Mouse
MGI:2444881
226844
Rat
Dog
feline leukemia virus subgroup C cellular receptor 1
100856001
Species
Name
OMA
EggNOG
Inparanoid
Chimp
feline leukemia virus subgroup C cellular receptor 1
Macaque
feline leukemia virus subgroup C cellular receptor 1
Mouse
Rat
Dog
feline leukemia virus subgroup C cellular receptor 1
Publication Statistics
PubMed Score 51.68
PubMed score by year
PubTator Score 31.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title