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Tchem
LIPG
Endothelial lipase

Protein Summary
Description
Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin. The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261292
  • ENSP00000261292
  • ENSG00000101670
  • ENST00000580036
  • ENSP00000462420

Symbol
  • EL
  • EDL
  • PRO719
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
protein domain
0.92
cell type or tissue
0.84
histone modification site profile
0.82
gene perturbation
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 230.98   (req: < 5)
Gene RIFs: 85   (req: <= 3)
Antibodies: 928   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 230.98   (req: >= 5)
Gene RIFs: 85   (req: > 3)
Antibodies: 928   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 464
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
20
18
39
3.6
99.7
total cholesterol measurement
8
8
20
96.7
low density lipoprotein cholesterol measurement
4
2
5
95.4
vitamin D measurement
2
3
3
84.3
apolipoprotein A 1 measurement
1
3
3
77.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
39
3.6
99.7
total cholesterol measurement
20
96.7
low density lipoprotein cholesterol measurement
5
95.4
vitamin D measurement
3
84.3
apolipoprotein A 1 measurement
3
77.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lipase G, endothelial type
VGNC:7815
455413
Macaque
lipase G, endothelial type
699477
Mouse
MGI:1341803
16891
Rat
RGD:1310740
291437
Dog
lipase G, endothelial type
VGNC:53618
609249
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lipase G, endothelial type
Macaque
lipase G, endothelial type
Mouse
Rat
Dog
lipase G, endothelial type
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y5X9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
HDL remodeling (R-HSA-8964058)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
HDL remodeling
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein remodeling
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
HDL remodeling
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein remodeling
Transport of small molecules
Protein-Protein Interactions (126)
1 – 10 of 126
DNAJC13
Tbio
Novelty: 0.03251995
p_int: 0.999998649
p_ni: 0.000001351
Data Source: BioPlex
TMED4
Tdark
Novelty: 0.22372593
p_int: 0.99994887
p_ni: 0.00005113
Score: 0.613
Data Source: BioPlex,STRINGDB
TUBB1
Tclin
Novelty: 0.02806117
p_int: 0.999852911
p_ni: 0.000147089
Data Source: BioPlex
TMED9
Tdark
Novelty: 0.24024246
p_int: 0.999546962
p_ni: 0.000453038
Score: 0.189
Data Source: BioPlex,STRINGDB
TMED5
Tdark
Novelty: 0.32104091
p_int: 0.998465656
p_ni: 0.001534344
Score: 0.828
Data Source: BioPlex,STRINGDB
TRMT1
Tbio
Family: Enzyme
Novelty: 0.01795504
p_int: 0.994320036
p_ni: 0.005679964
Score: 0.19
Data Source: BioPlex,STRINGDB
PLS1
Tbio
Novelty: 0.00538817
p_int: 0.993185195
p_ni: 0.006814805
Data Source: BioPlex
PTPRS
Tchem
Family: Enzyme
Novelty: 0.00587115
p_int: 0.98734813
p_ni: 0.01265187
Data Source: BioPlex
NRP1
Tchem
Novelty: 0.00153628
p_int: 0.983845553
p_ni: 0.016154447
Data Source: BioPlex
TMED10
Tbio
Novelty: 0.02742083
p_int: 0.982460412
p_ni: 0.017539588
Score: 0.667
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  230.98

PubMed score by year
PubTator Score  140.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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