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Tchem
NPFFR2
Neuropeptide FF receptor 2

Protein Summary
Description
Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308744
  • ENSP00000307822
  • ENSG00000056291
  • ENST00000344413
  • ENSP00000340789
  • ENST00000358749
  • ENSP00000351599
  • ENST00000395999
  • ENSP00000379321

Symbol
  • GPR74
  • NPFF2
  • NPGPR
  • GPR74
  • NPFF2
  • NPGPR
  • HLWAR77
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein)
0.68
virus perturbation
0.64
molecular function
0.63
protein domain
0.58
biological process
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.33   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.33   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 18
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (18)
(R)-argininamide
Rendered image for (R)-argininamide
CHEMBL2208319
Rendered image for CHEMBL2208319
CHEMBL2208338
Rendered image for CHEMBL2208338
CHEMBL2208322
Rendered image for CHEMBL2208322
CHEMBL2208340
Rendered image for CHEMBL2208340
CHEMBL1672380
Rendered image for CHEMBL1672380
CHEMBL3360829
Rendered image for CHEMBL3360829
CHEMBL2208339
Rendered image for CHEMBL2208339
CHEMBL2208325
Rendered image for CHEMBL2208325
Protein-Protein Interactions (188)
NPFF
Tbio
Novelty:  0.00489546
Score:  0.994
Data Source:  Reactome,STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.978
Data Source:  STRINGDB
QRFP
Tbio
Novelty:  0.02210773
Score:  0.969
Data Source:  STRINGDB
HCRT
Tbio
Novelty:  0.00034048
Score:  0.965
Data Source:  STRINGDB
TAC1
Tbio
Novelty:  0.00006575
Score:  0.962
Data Source:  STRINGDB
NTS
Tbio
Novelty:  0.00033201
Score:  0.96
Data Source:  STRINGDB
GNRH1
Tbio
Novelty:  0.00020807
Score:  0.955
Data Source:  STRINGDB
KISS1
Tbio
Novelty:  0.00096537
Score:  0.952
Data Source:  STRINGDB
OXT
Tbio
Novelty:  0.00005116
Score:  0.95
Data Source:  STRINGDB
GRP
Tbio
Novelty:  0.00034247
Score:  0.949
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Orexin and neuropeptides FF and QRFP bind to their respective receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Orexin and neuropeptides FF and QRFP bind to their respective receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
4
15
14
6.1
99
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
14
6.1
99
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuropeptide FF receptor 2
VGNC:649
471213
Macaque
neuropeptide FF receptor 2
705590
Mouse
MGI:1860130
104443
Rat
RGD:620168
78964
Dog
neuropeptide FF receptor 2
VGNC:43917
100686684
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuropeptide FF receptor 2
Macaque
neuropeptide FF receptor 2
Mouse
Rat
Dog
neuropeptide FF receptor 2
Publication Statistics
PubMed Score 56.33
PubMed score by year
PubTator Score 26.74
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title