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Tchem
NPFFR2
Neuropeptide FF receptor 2

Protein Summary
Description
Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308744
  • ENSP00000307822
  • ENSG00000056291
  • ENST00000344413
  • ENSP00000340789
  • ENST00000358749
  • ENSP00000351599
  • ENST00000395999
  • ENSP00000379321

Symbol
  • GPR74
  • NPFF2
  • NPGPR
  • GPR74
  • NPFF2
  • NPGPR
  • HLWAR77
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein)
0.68
virus perturbation
0.64
molecular function
0.63
protein domain
0.58
biological process
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.48   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.48   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
3
2
6.1
98.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
2
6.1
98.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuropeptide FF receptor 2
VGNC:649
471213
Macaque
neuropeptide FF receptor 2
705590
Mouse
MGI:1860130
104443
Rat
RGD:620168
78964
Dog
neuropeptide FF receptor 2
VGNC:43917
100686684
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuropeptide FF receptor 2
Macaque
neuropeptide FF receptor 2
Mouse
Rat
Dog
neuropeptide FF receptor 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y5X5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Orexin and neuropeptides FF and QRFP bind to their respective receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Orexin and neuropeptides FF and QRFP bind to their respective receptors
Protein-Protein Interactions (188)
1 – 10 of 188
NPFF
Tbio
Novelty: 0.00489546
Score: 0.994
Data Source: Reactome,STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.978
Data Source: STRINGDB
QRFP
Tbio
Novelty: 0.02210773
Score: 0.969
Data Source: STRINGDB
HCRT
Tbio
Novelty: 0.00034048
Score: 0.965
Data Source: STRINGDB
TAC1
Tbio
Novelty: 0.00006575
Score: 0.962
Data Source: STRINGDB
NTS
Tbio
Novelty: 0.00033201
Score: 0.96
Data Source: STRINGDB
GNRH1
Tbio
Novelty: 0.00020807
Score: 0.955
Data Source: STRINGDB
KISS1
Tbio
Novelty: 0.00096537
Score: 0.952
Data Source: STRINGDB
OXT
Tbio
Novelty: 0.00005116
Score: 0.95
Data Source: STRINGDB
GRP
Tbio
Novelty: 0.00034247
Score: 0.949
Data Source: STRINGDB
Publication Statistics
PubMed Score  51.48

PubMed score by year
PubTator Score  26.74

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer