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Tchem
NR2E3
Photoreceptor-specific nuclear receptor

Protein Summary
Description
Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression. This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000617575
  • ENSP00000482504
  • ENSG00000278570
  • ENST00000621098
  • ENSP00000479962

Symbol
  • PNR
  • RNR
  • PNR
  • RNR
  • rd7
  • ESCS
  • RP37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
biological process
0.82
cell type or tissue
0.8
molecular function
0.79
microRNA
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.88   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.88   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL386138
Rendered image for CHEMBL386138
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
1
2
73
urate measurement
2
2
2
72.5
hemoglobin measurement
2
1
2
71.9
triglyceride measurement
2
2
1
5.9
45.6
erythrocyte count
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
73
urate measurement
2
72.5
hemoglobin measurement
2
71.9
triglyceride measurement
1
5.9
45.6
erythrocyte count
1
38.8
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
nuclear receptor subfamily 2 group E member 3
701402
Mouse
MGI:1346317
23958
Cow
nuclear receptor subfamily 2 group E member 3
VGNC:32239
281944
Chicken
nuclear receptor subfamily 2 group E member 3
CGNC:49244
395289
Xenopus
nuclear receptor subfamily 2 group E member 3
XB-GENE-485801
100036597
Species
Name
OMA
EggNOG
Inparanoid
Macaque
nuclear receptor subfamily 2 group E member 3
Mouse
Cow
nuclear receptor subfamily 2 group E member 3
Chicken
nuclear receptor subfamily 2 group E member 3
Xenopus
nuclear receptor subfamily 2 group E member 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y5X4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Nuclear Receptor transcription pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Nuclear Receptor transcription pathway
RNA Polymerase II Transcription
Gene Ontology Terms (21)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred by Curator (IC)
NTNU_SB
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (120)
1 – 10 of 120
CRX
Tbio
Family:  TF
Novelty:  0.00278097
Score:  0.947
Data Source:  STRINGDB
NRL
Tbio
Family:  TF
Novelty:  0.00197314
Score:  0.94
Data Source:  STRINGDB
RHO
Tbio
Family:  GPCR
Novelty:  0.00012925
Score:  0.826
Data Source:  STRINGDB
RPE65
Tbio
Family:  Enzyme
Novelty:  0.00147985
Score:  0.694
Data Source:  STRINGDB
VSX2
Tbio
Family:  TF
Novelty:  0.0046733
Score:  0.682
Data Source:  STRINGDB
PDE6B
Tclin
Family:  Enzyme
Novelty:  0.001105
Score:  0.681
Data Source:  STRINGDB
PRPH2
Tbio
Novelty:  0.003038
Score:  0.676
Data Source:  STRINGDB
OPN1SW
Tbio
Family:  GPCR
Novelty:  0.00688397
Score:  0.654
Data Source:  STRINGDB
OTX2
Tbio
Family:  TF
Novelty:  0.0024536
Score:  0.644
Data Source:  STRINGDB
MFRP
Tbio
Novelty:  0.00952961
Score:  0.643
Data Source:  STRINGDB
Publication Statistics
PubMed Score  176.88

PubMed score by year
PubTator Score  111.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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