You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
NR2E3
Photoreceptor-specific nuclear receptor

Protein Summary
Description
Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression. This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000617575
  • ENSP00000482504
  • ENSG00000278570
  • ENST00000621098
  • ENSP00000479962

Symbol
  • PNR
  • RNR
  • PNR
  • RNR
  • rd7
  • ESCS
  • RP37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
biological process
0.82
cell type or tissue
0.8
molecular function
0.79
microRNA
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.65   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.65   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0