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Tbio
SNX5
Sorting nexin-5

Protein Summary
Description
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377759
  • ENSP00000366988
  • ENSG00000089006
  • ENST00000377768
  • ENSP00000366998
  • ENST00000606557
  • ENSP00000475510
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
transcription factor binding site profile
0.95
interacting protein
0.92
virus perturbation
0.9
cellular component
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.99   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.99   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (138)
SNX1
Tbio
Novelty:  0.01267973
p_int:  0.999999997
p_ni:  3e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
C1orf87
Tbio
Novelty:  0.03162594
p_int:  0.9999979
p_ni:  0.000002099
Score:  0.313
Data Source:  BioPlex,STRINGDB
BIN3
Tbio
Novelty:  0.02034119
p_int:  0.999726834
p_ni:  0.000273166
Score:  0.558
Data Source:  BioPlex,STRINGDB
SEMA4C
Tbio
Novelty:  0.01237067
p_int:  0.999601163
p_ni:  0.000398837
Data Source:  BioPlex
HYOU1
Tbio
Novelty:  0.00833649
p_int:  0.998960686
p_ni:  0.001039314
Data Source:  BioPlex
C11orf42
Tdark
Novelty:  3.71428571
p_int:  0.998330124
p_ni:  0.001669874
p_wrong:  2e-9
Score:  0.345
Data Source:  BioPlex,STRINGDB
CCDC102B
Tdark
Novelty:  0.28075569
p_int:  0.994776795
p_ni:  0.005222377
p_wrong:  8.28e-7
Data Source:  BioPlex
TOM1
Tbio
Novelty:  0.00725956
p_int:  0.985183597
p_ni:  0.014816403
Data Source:  BioPlex
SPANXB1
Tbio
Novelty:  0.19187624
p_int:  0.975981556
p_ni:  0.024018444
Data Source:  BioPlex
GAS2L1
Tbio
Novelty:  0.17484834
p_int:  0.964736141
p_ni:  0.035257829
p_wrong:  0.00000603
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Golgi Associated Vesicle Biogenesis (R-HSA-432722)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Reactome
trans-Golgi Network Vesicle Budding
Name
Explore in Pharos
Explore in Source
Golgi Associated Vesicle Biogenesis
Membrane Trafficking
Vesicle-mediated transport
trans-Golgi Network Vesicle Budding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Non-traceable Author Statement (NAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
9
5
12
95.1
apolipoprotein B measurement
2
2
2
83.1
mitochondrial DNA measurement
1
1
1
75.4
total cholesterol measurement
4
3
7
71.2
mean corpuscular hemoglobin concentration
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
12
95.1
apolipoprotein B measurement
2
83.1
mitochondrial DNA measurement
1
75.4
total cholesterol measurement
7
71.2
mean corpuscular hemoglobin concentration
1
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 5
VGNC:6268
458110
Macaque
sorting nexin 5
698897
Mouse
MGI:1916428
69178
Rat
RGD:1310190
296199
Dog
sorting nexin 5
VGNC:46642
100855895
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 5
Macaque
sorting nexin 5
Mouse
Rat
Dog
sorting nexin 5
Publication Statistics
PubMed Score 34.99
PubMed score by year
PubTator Score 14.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title