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Tbio
SNX9
Sorting nexin-9

Protein Summary
Description
Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392185
  • ENSP00000376024
  • ENSG00000130340

Symbol
  • SH3PX1
  • SH3PXD3A
  • SDP1
  • WISP
  • SH3PX1
  • SH3PXD3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
kinase perturbation
0.84
disease perturbation
0.83
microRNA
0.79
biological process
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.49   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 345   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.49   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 345   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
65.3
alkaline phosphatase measurement
1
1
1
56.6
heart rate
1
1
0
3.5
24.5
response to beta blocker
1
1
0
3.5
24.5
serum gamma-glutamyl transferase measurement
1
1
1
24.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
65.3
alkaline phosphatase measurement
1
56.6
heart rate
0
3.5
24.5
response to beta blocker
0
3.5
24.5
serum gamma-glutamyl transferase measurement
1
24.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 9
VGNC:3707
472172
Macaque
sorting nexin 9
706016
Mouse
MGI:1913866
66616
Rat
RGD:1584466
683687
Dog
sorting nexin 9
VGNC:46645
476254
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 9
Macaque
sorting nexin 9
Mouse
Rat
Dog
sorting nexin 9
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y5X1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Reactome
trans-Golgi Network Vesicle Budding
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Golgi Associated Vesicle Biogenesis
Membrane Trafficking
Vesicle-mediated transport
trans-Golgi Network Vesicle Budding
Gene Ontology Terms (30)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (228)
1 – 10 of 228
SYNJ1
Tchem
Novelty:  0.01030746
p_int:  0.999999961
p_ni:  2e-9
p_wrong:  3.6e-8
Score:  0.981
Data Source:  BioPlex,STRINGDB
DNM1
Tbio
Novelty:  0.00319082
p_int:  0.999997121
p_ni:  0.000002879
Score:  0.99
Data Source:  BioPlex,STRINGDB
DNM3
Tbio
Novelty:  0.02365643
p_int:  0.999996715
p_ni:  0.000003281
p_wrong:  3e-9
Score:  0.976
Data Source:  BioPlex,STRINGDB
AP2A1
Tbio
Novelty:  0.08554974
p_int:  0.999708002
p_ni:  0.000291998
Score:  0.911
Data Source:  BioPlex,STRINGDB
FCHSD1
Tdark
Novelty:  0.53501769
p_int:  0.999633505
p_ni:  0.000066399
p_wrong:  0.000300097
Score:  0.856
Data Source:  BioPlex,STRINGDB
MLYCD
Tchem
Family:  Enzyme
Novelty:  0.01670441
p_int:  0.998848831
p_ni:  0.000496127
p_wrong:  0.000655042
Data Source:  BioPlex
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.997413644
p_ni:  0.002586356
Score:  0.964
Data Source:  BioPlex,STRINGDB
AP2A2
Tbio
Novelty:  0.08851191
p_int:  0.99236415
p_ni:  0.00763585
Score:  0.928
Data Source:  BioPlex,STRINGDB
AP1B1
Tbio
Novelty:  0.03370208
p_int:  0.987258972
p_ni:  0.012741026
p_wrong:  2e-9
Score:  0.915
Data Source:  BioPlex,STRINGDB
DPPA4
Tbio
Novelty:  0.05764302
p_int:  0.983617217
p_ni:  0.016382783
Score:  0.198
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  72.49

PubMed score by year
PubTator Score  46.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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