Tbio SNX11 Sorting nexin-11

Protein Summary

Description

Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene encodes a protein of unknown function. This gene results in two transcript variants differing in the 5' UTR, but encoding the same protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y5W9
• B3KRL6
• B4DPY5
• D3DTV0
• Q53YC0
• Q9H885

Gene Name

• SNX11

Ensembl ID

• ENST00000359238
• ENSP00000352175
• ENSG00000002919
• ENST00000393405
• ENSP00000377059
• ENST00000580219
• ENSP00000462188
• ENST00000582104
• ENSP00000463948

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.87
disease perturbation	0.74
transcription factor	0.74
tissue sample	0.64
tissue	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.13   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 129   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.13   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0