Tbio SNX13 Sorting nexin-13

Protein Summary

Description

May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis (By similarity). Acts as a GAP for Galphas. This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y5W8
• B2RCI9
• O94821
• Q8WVZ2
• Q8WXH8

Gene Name

• SNX13

Ensembl ID

• ENST00000428135
• ENSP00000398789
• ENSG00000071189

Symbol

• KIAA0713
• RGS-PX1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.85
histone modification site profile	0.81
transcription factor perturbation	0.8
transcription factor binding site profile	0.79
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Sorting Nexin-13

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Sorting Nexin-13

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.23   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 82   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.23   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0