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Tbio
SNX14
Sorting nexin-14

Protein Summary
Description
Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes (Probable). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes (PubMed:25848753). Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:25848753, PubMed:25148684). This gene encodes a member of the sorting nexin family. Members of this family have a phox (PX) phosphoinositide binding domain and are involved in intracellular trafficking. The encoded protein also contains a regulator of G protein signaling (RGS) domain. Regulator of G protein signaling family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. Alternate splicing results in transcript variants encoding distinct isoforms. [ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314673
  • ENSP00000313121
  • ENSG00000135317
  • ENST00000346348
  • ENSP00000257769
  • ENST00000369627
  • ENSP00000358641
  • ENST00000505648
  • ENSP00000427380

Symbol
  • SCAR20
  • RGS-PX2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
interacting protein
0.85
transcription factor binding site profile
0.83
tissue sample
0.68
cell line
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.52   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.52   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (83)
1 – 10 of 83
TSPAN2
Tbio
Novelty: 0.03842973
p_int: 0.999998088
p_ni: 0.000001911
p_wrong: 1e-9
Data Source: BioPlex
ZNRF4
Tbio
Novelty: 0.16505328
p_int: 0.998087304
p_ni: 0.001912696
Data Source: BioPlex
ANKRD9
Tdark
Novelty: 0.43181793
p_int: 0.997241142
p_ni: 0.002758776
p_wrong: 8.2e-8
Data Source: BioPlex
CNGA3
Tchem
Family: IC
Novelty: 0.00818181
p_int: 0.99448275
p_ni: 0.005517077
p_wrong: 1.73e-7
Score: 0.151
Data Source: BioPlex,STRINGDB
MCOLN3
Tchem
Family: IC
Novelty: 0.03209262
p_int: 0.993824357
p_ni: 0.0061614
p_wrong: 0.000014242
Data Source: BioPlex
IPPK
Tbio
Family: Enzyme
Novelty: 0.02169701
p_int: 0.9925715
p_ni: 0.007428498
p_wrong: 2e-9
Data Source: BioPlex
SLC4A8
Tbio
Family: Transporter
Novelty: 0.01606111
p_int: 0.992428443
p_ni: 0.007571548
p_wrong: 9e-9
Data Source: BioPlex
CHRNA9
Tchem
Family: IC
Novelty: 0.05009815
p_int: 0.991448161
p_ni: 0.00855183
p_wrong: 9e-9
Data Source: BioPlex
SIGLECL1
Tdark
p_int: 0.990759842
p_ni: 0.009233273
p_wrong: 0.000006886
Data Source: BioPlex
PCDHGA5
Tdark
Novelty: 2.13631603
p_int: 0.989399787
p_ni: 0.010600179
p_wrong: 3.4e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  15.52

PubMed score by year
PubTator Score  7.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer