Tbio WIF1 Wnt inhibitory factor 1

Protein Summary

Description

Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation. The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• Q9Y5W5
• Q6UXI1
• Q8WVG4
• WIF-1

Gene Name

• WIF1

Ensembl ID

• ENST00000286574
• ENSP00000286574
• ENSG00000156076

Symbol

• WIF-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.85
PubMedID	0.81
biological term	0.74
histone modification site profile	0.67
trait	0.61

Protein Classes

PANTHER Classes

Protein / Calcium-binding Protein / Wnt Inhibitory Factor 1

DTO Classes

Protein / Calcium-binding Protein / Wnt Inhibitory Factor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 232.66   (req: < 5)

Gene RIFs: 125   (req: <= 3)

Antibodies: 463   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 232.66   (req: >= 5)

Gene RIFs: 125   (req: > 3)

Antibodies: 463   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0