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Tbio
KLF2
Krueppel-like factor 2

Protein Summary
Description
Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processes during development and disease including adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and t-cell viability. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248071
  • ENSP00000248071
  • ENSG00000127528

Symbol
  • LKLF
  • LKLF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
small molecule perturbation
0.93
biological process
0.9
gene perturbation
0.85
biological term
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 408.06   (req: < 5)
Gene RIFs: 122   (req: <= 3)
Antibodies: 400   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 408.06   (req: >= 5)
Gene RIFs: 122   (req: > 3)
Antibodies: 400   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
78.4
lymphocyte count
2
2
2
67.1
lymphocyte percentage of leukocytes
2
2
3
63.5
neutrophil percentage of leukocytes
2
2
3
53.5
eosinophil percentage of leukocytes
1
2
2
43.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
78.4
lymphocyte count
2
67.1
lymphocyte percentage of leukocytes
3
63.5
neutrophil percentage of leukocytes
3
53.5
eosinophil percentage of leukocytes
2
43.3
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Kruppel like factor 2
VGNC:11146
748298
Mouse
MGI:1342772
16598
Rat
RGD:1359220
306330
Opossum
Kruppel like factor 2
100014710
Chicken
Kruppel like factor 2
CGNC:2890
420148
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Kruppel like factor 2
Mouse
Rat
Opossum
Kruppel like factor 2
Chicken
Kruppel like factor 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y5W3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
FoxO signaling pathway
KEGG
Apelin signaling pathway
KEGG
Fluid shear stress and atherosclerosis
Name
Explore in Pharos
Explore in Source
FoxO signaling pathway
Apelin signaling pathway
Fluid shear stress and atherosclerosis
Protein-Protein Interactions (127)
1 – 10 of 127
S1PR1
Tclin
Family: GPCR
Novelty: 0.00162513
Score: 0.882
Data Source: STRINGDB
FOXO1
Tbio
Family: TF
Novelty: 0.00058938
Score: 0.878
Data Source: STRINGDB
NFKB1
Tclin
Family: TF
Novelty: 0.00198195
Score: 0.848
Data Source: STRINGDB
RELA
Tchem
Family: TF
Novelty: 0.0007137
Score: 0.844
Data Source: STRINGDB
NOS3
Tchem
Family: Enzyme
Novelty: 0.00012407
Score: 0.844
Data Source: STRINGDB
SELL
Tchem
Novelty: 0.00030025
Score: 0.802
Data Source: STRINGDB
MYC
Tbio
Family: TF
Novelty: 0.00005734
Score: 0.786
Data Source: STRINGDB
MAPK7
Tchem
Family: Kinase
Novelty: 0.00257226
Score: 0.77
Data Source: STRINGDB
THBD
Tbio
Novelty: 0.00039359
Score: 0.758
Data Source: STRINGDB
NANOG
Tbio
Family: TF
Novelty: 0.00054893
Score: 0.755
Data Source: STRINGDB
Publication Statistics
PubMed Score  408.06

PubMed score by year
PubTator Score  167.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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