MAGED1
Melanoma-associated antigen D1
Protein Summary
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed. This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has bee ...more
- ENST00000326587
- ENSP00000325333
- ENSG00000179222
- ENST00000375695
- ENSP00000364847
- ENST00000375722
- ENSP00000364874
- ENST00000375772
- ENSP00000364927
- NRAGE
- NRAGE
- DLXIN-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.99 | ||
kinase perturbation | 0.91 | ||
biological process | 0.86 | ||
histone modification site profile | 0.83 | ||
disease perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.24 (req: < 5)
Gene RIFs: 27 (req: <= 3)
Antibodies: 328 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.24 (req: >= 5)
Gene RIFs: 27 (req: > 3)
Antibodies: 328 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (57)
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (24)
Reactome (9)
KEGG (1)
PathwayCommons (2)
WikiPathways (12)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Apoptosis | ||||
Reactome | Caspase activation via Dependence Receptors in the absence of ligand | ||||
Reactome | Caspase activation via extrinsic apoptotic signalling pathway | ||||
Reactome | Cell death signalling via NRAGE, NRIF and NADE | ||||
Reactome | Death Receptor Signalling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Apoptosis | ||||
Caspase activation via Dependence Receptors in the absence of ligand | ||||
Caspase activation via extrinsic apoptotic signalling pathway | ||||
Cell death signalling via NRAGE, NRIF and NADE | ||||
Death Receptor Signalling | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (2)
Components (5)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | MAGE family member D1 | 696658 | ||||||
Mouse | MGI:1930187 | 94275 | ||||||
Rat | RGD:70898 | 84469 | ||||||
Dog | MAGE family member D1 | VGNC:42924 | 480923 | |||||
Cow | melanoma antigen family D, 1 | 512562 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | MAGE family member D1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | MAGE family member D1 | |||||
Cow | melanoma antigen family D, 1 | |||||
Publication Statistics
PubMed Score 58.24
PubMed score by year
PubTator Score 33.58
PubTator score by year
Related Publications
Text Mined References (51)
GeneRif Annotations (27)
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