Tbio MAGED1 Melanoma-associated antigen D1

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / Melanoma-associated Antigen D1

DTO Classes

Protein / Cell Adhesion / Melanoma-associated Antigen D1

Protein Summary

Description

Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed. This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y5V3
• Q5VSH6
• Q8IZ84
• Q8WY92
• Q9H352
• Q9HBT4
• Q9UF36

Gene Name

• MAGED1

Ensembl ID

• ENST00000326587
• ENSP00000325333
• ENSG00000179222
• ENST00000375695
• ENSP00000364847
• ENST00000375722
• ENSP00000364874
• ENST00000375772
• ENSP00000364927

Symbol

• NRAGE
• NRAGE
• DLXIN-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
kinase perturbation	0.91
biological process	0.86
histone modification site profile	0.83
disease perturbation	0.79

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.05   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 328   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.05   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (24)

Reactome (9)

KEGG (1)

PathwayCommons (2)

WikiPathways (12)

Apoptosis (R-HSA-109581)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Apoptosis	177 targets	R-HSA-109581
Reactome	Caspase activation via Dependence Receptors in the absence of ligand	10 targets	R-HSA-418889
Reactome	Caspase activation via extrinsic apoptotic signalling pathway	26 targets	R-HSA-5357769
Reactome	Cell death signalling via NRAGE, NRIF and NADE	76 targets	R-HSA-204998
Reactome	Death Receptor Signalling	141 targets	R-HSA-73887

Name	Explore in Pharos	Explore in Source
Apoptosis	177 targets	R-HSA-109581
Caspase activation via Dependence Receptors in the absence of ligand	10 targets	R-HSA-418889
Caspase activation via extrinsic apoptotic signalling pathway	26 targets	R-HSA-5357769
Cell death signalling via NRAGE, NRIF and NADE	76 targets	R-HSA-204998
Death Receptor Signalling	141 targets	R-HSA-73887

Gene Ontology Terms (18)

Functions (2)

Components (5)

Processes (11)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
transcription coactivator activity	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (57)

Explore Interacting Targets

1 – 10 of 57

• See Interactions on String-DB

NGFR

Tclin

Novelty: 0.00072052

Score: 0.982

Data Source: Reactome,STRINGDB

AATF

Tbio

Novelty: 0.01637464

Score: 0.977

Data Source: Reactome,STRINGDB

UNC5A

Tbio

Novelty: 0.03749855

Score: 0.976

Data Source: Reactome,STRINGDB

NTRK1

Tclin

Family: Kinase

Novelty: 0.00033453

Score: 0.961

Data Source: STRINGDB

SORT1

Tchem

Novelty: 0.00319862

Score: 0.939

Data Source: STRINGDB

NGF

Tchem

Novelty: 0.00008139

Score: 0.938

Data Source: Reactome,STRINGDB

MAPK8

Tchem

Family: Kinase

Novelty: 0.00055723

Score: 0.926

Data Source: Reactome,STRINGDB

CASP3

Tchem

Family: Enzyme

Novelty: 0.00003555

Score: 0.912

Data Source: STRINGDB

MAPK9

Tchem

Family: Kinase

Novelty: 0.00267199

Score: 0.908

Data Source: STRINGDB

CYCS

Tchem

Novelty: 0.00014004

Score: 0.906

Data Source: STRINGDB

Publication Statistics

PubMed Score  58.05

PubMed score by year

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PubTator Score  33.58

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Alternative splicing
Biological rhythms
Cell membrane
Complete proteome
Cytoplasm
Membrane
Nucleus
Phosphoprotein
Polymorphism
Reference proteome

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
cellular phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
nervous system phenotype
vision/eye phenotype