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Tbio
MAGED1
Melanoma-associated antigen D1

Protein Summary
Description
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed. This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has bee ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326587
  • ENSP00000325333
  • ENSG00000179222
  • ENST00000375695
  • ENSP00000364847
  • ENST00000375722
  • ENSP00000364874
  • ENST00000375772
  • ENSP00000364927

Symbol
  • NRAGE
  • NRAGE
  • DLXIN-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase perturbation
0.91
biological process
0.86
histone modification site profile
0.83
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.05   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 328   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.05   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (24)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Caspase activation via Dependence Receptors in the absence of ligand
Reactome
Caspase activation via extrinsic apoptotic signalling pathway
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Name
Explore in Pharos
Explore in Source
Apoptosis
Caspase activation via Dependence Receptors in the absence of ligand
Caspase activation via extrinsic apoptotic signalling pathway
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (57)
1 – 10 of 57
NGFR
Tclin
Novelty: 0.00072052
Score: 0.982
Data Source: Reactome,STRINGDB
AATF
Tbio
Novelty: 0.01637464
Score: 0.977
Data Source: Reactome,STRINGDB
UNC5A
Tbio
Novelty: 0.03749855
Score: 0.976
Data Source: Reactome,STRINGDB
NTRK1
Tclin
Family: Kinase
Novelty: 0.00033453
Score: 0.961
Data Source: STRINGDB
SORT1
Tchem
Novelty: 0.00319862
Score: 0.939
Data Source: STRINGDB
NGF
Tchem
Novelty: 0.00008139
Score: 0.938
Data Source: Reactome,STRINGDB
MAPK8
Tchem
Family: Kinase
Novelty: 0.00055723
Score: 0.926
Data Source: Reactome,STRINGDB
CASP3
Tchem
Family: Enzyme
Novelty: 0.00003555
Score: 0.912
Data Source: STRINGDB
MAPK9
Tchem
Family: Kinase
Novelty: 0.00267199
Score: 0.908
Data Source: STRINGDB
CYCS
Tchem
Novelty: 0.00014004
Score: 0.906
Data Source: STRINGDB
Publication Statistics
PubMed Score  58.05

PubMed score by year
PubTator Score  33.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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