You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
ZNF706
Zinc finger protein 706

Protein Summary
Description
Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal. Acts by repressing expression of KLF4.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311212
  • ENSP00000311768
  • ENSG00000120963
  • ENST00000517844
  • ENSP00000428227
  • ENST00000518336
  • ENSP00000428696
  • ENST00000519882
  • ENSP00000428985
  • ENST00000520347
  • ENSP00000430823
  • ENST00000520984
  • ENSP00000427761
  • ENST00000521272
  • ENSP00000430165

Symbol
  • HSPC038
  • PNAS-106
  • PNAS-113
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
1
transcription factor binding site profile
0.97
histone modification site profile
0.86
virus perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.1   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.1   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
SP100
Tbio
Family:  TF; Epigenetic
Novelty:  0.00201806
p_int:  0.819381864
p_ni:  0.000017075
p_wrong:  0.180601061
Score:  0.692
Data Source:  BioPlex,STRINGDB
TRIM28
Tbio
Family:  Epigenetic
Novelty:  0.00778381
Score:  0.9
Data Source:  STRINGDB
TXNDC5
Tbio
Novelty:  0.02369481
Score:  0.815
Data Source:  STRINGDB
ATP6V1A
Tbio
Family:  Enzyme
Novelty:  0.00921474
Score:  0.777
Data Source:  STRINGDB
CLNS1A
Tbio
Novelty:  0.01824362
Score:  0.727
Data Source:  STRINGDB
SLA
Tbio
Novelty:  0.01923631
Score:  0.615
Data Source:  STRINGDB
PCDHB15
Tdark
Novelty:  1.37571583
Score:  0.598
Data Source:  STRINGDB
ELP2
Tbio
Novelty:  0.03034629
Score:  0.525
Data Source:  STRINGDB
RNF180
Tbio
Family:  Enzyme
Novelty:  0.10090735
Score:  0.517
Data Source:  STRINGDB
PYM1
Tbio
Novelty:  0.04117785
Score:  0.512
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc finger protein 706
710457
Mouse
MGI:1915286
68036
Dog
zinc finger protein 706
VGNC:48804
607293
Horse
zinc finger protein 706
VGNC:25378
100629307
Cow
zinc finger protein 706
VGNC:37336
614279
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc finger protein 706
Mouse
Dog
zinc finger protein 706
Horse
zinc finger protein 706
Cow
zinc finger protein 706
Publication Statistics
PubMed Score 4.10
PubMed score by year
PubTator Score 3.77
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title