Tdark ZNF706 Zinc finger protein 706

Protein Summary

Description

Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal. Acts by repressing expression of KLF4.

Uniprot Accession IDs

• Q9Y5V0
• A8K362

Gene Name

• ZNF706

Ensembl ID

• ENST00000311212
• ENSP00000311768
• ENSG00000120963
• ENST00000517844
• ENSP00000428227
• ENST00000518336
• ENSP00000428696
• ENST00000519882
• ENSP00000428985
• ENST00000520347
• ENSP00000430823
• ENST00000520984
• ENSP00000427761
• ENST00000521272
• ENSP00000430165

Symbol

• HSPC038
• PNAS-106
• PNAS-113

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
transcription factor perturbation	1
transcription factor binding site profile	0.97
histone modification site profile	0.86
virus perturbation	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.63   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 36   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.63   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0