Protein Summary
Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal. Acts by repressing expression of KLF4.
- ENST00000311212
- ENSP00000311768
- ENSG00000120963
- ENST00000517844
- ENSP00000428227
- ENST00000518336
- ENSP00000428696
- ENST00000519882
- ENSP00000428985
- ENST00000520347
- ENSP00000430823
- ENST00000520984
- ENSP00000427761
- ENST00000521272
- ENSP00000430165
- HSPC038
- PNAS-106
- PNAS-113
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
transcription factor perturbation | 1 | ||
transcription factor binding site profile | 0.97 | ||
histone modification site profile | 0.86 | ||
virus perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.63 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 36 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.63 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 36 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0