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Tbio
MPC1
Mitochondrial pyruvate carrier 1

Protein Summary
Description
Mediates the uptake of pyruvate into mitochondria. The protein encoded by this gene is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate into mitochondria. The encoded protein is found in the inner mitochondrial membrane. Defects in this gene are a cause of mitochondrial pyruvate carrier deficiency. Several transcript variants, some protein coding and one non-protein coding, have been found for this gene. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360961
  • ENSP00000354223
  • ENSG00000060762

Symbol
  • BRP44L
  • MPYCD
  • BRP44L
  • CGI-129
  • SLC54A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
transcription factor perturbation
0.91
histone modification site profile
0.89
kinase perturbation
0.81
transcription factor binding site profile
0.69


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.32   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.32   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial pyruvate carrier 1
VGNC:3488
737234
Macaque
mitochondrial pyruvate carrier 1
716864
Mouse
MGI:1915240
55951
Rat
RGD:620902
171087
Horse
mitochondrial pyruvate carrier 1 [Source:HGNC Symbol;Acc:HGNC:21606]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial pyruvate carrier 1
Macaque
mitochondrial pyruvate carrier 1
Mouse
Rat
Horse
mitochondrial pyruvate carrier 1 [Source:HGNC Symbol;Acc:HGNC:21606]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y5U8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Pyruvate metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (36)
1 – 10 of 36
MPC2
Tbio
Novelty:  0.02948696
p_int:  0.998104717
p_ni:  0.001895281
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
ASS1
Tbio
Family:  Enzyme
Novelty:  0.00358761
p_int:  0.985499765
p_ni:  0.014500235
Data Source:  BioPlex
SRSF5
Tbio
Novelty:  0.01658346
Score:  0.818
Data Source:  STRINGDB
GLB1
Tchem
Family:  Enzyme
Novelty:  0.00241713
Score:  0.641
Data Source:  STRINGDB
PRR18
Tdark
Novelty:  1.18933147
Score:  0.575
Data Source:  STRINGDB
RPS6
Tbio
Novelty:  0.00122241
Score:  0.575
Data Source:  STRINGDB
ITGA5
Tbio
Novelty:  0.00285802
Score:  0.551
Data Source:  STRINGDB
SFT2D1
Tdark
Novelty:  0.56703167
Score:  0.55
Data Source:  STRINGDB
RPS6KA2
Tchem
Family:  Kinase
Novelty:  0.00409407
Score:  0.54
Data Source:  STRINGDB
UQCRFS1
Tbio
Novelty:  0.00341256
Score:  0.538
Data Source:  STRINGDB
Publication Statistics
PubMed Score  89.32

PubMed score by year
PubTator Score  36.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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