Tbio MPC1 Mitochondrial pyruvate carrier 1

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc54 Mitochondrial Pyruvate Carriers / Mitochondrial Pyruvate Carrier 1

Protein Summary

Description

Mediates the uptake of pyruvate into mitochondria. The protein encoded by this gene is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate into mitochondria. The encoded protein is found in the inner mitochondrial membrane. Defects in this gene are a cause of mitochondrial pyruvate carrier deficiency. Several transcript variants, some protein coding and one non-protein coding, have been found for this gene. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• Q9Y5U8
• B2R5I7
• Q5TI66
• Q9HB67
• Q9UQN4

Gene Name

• MPC1

Ensembl ID

• ENST00000360961
• ENSP00000354223
• ENSG00000060762

Symbol

• BRP44L
• MPYCD
• BRP44L
• CGI-129
• SLC54A1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
transcription factor perturbation	0.91
histone modification site profile	0.89
kinase perturbation	0.81
transcription factor binding site profile	0.69

Related Tools

RESOLUTE

RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.32   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 127   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.32   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	mitochondrial pyruvate carrier 1	VGNC:3488	737234
Macaque	mitochondrial pyruvate carrier 1		716864
Mouse	mitochondrial pyruvate carrier 1	MGI:1915240	55951
Rat	mitochondrial pyruvate carrier 1	RGD:620902	171087
Horse	mitochondrial pyruvate carrier 1 [Source:HGNC Symbol;Acc:HGNC:21606]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	mitochondrial pyruvate carrier 1
Macaque	mitochondrial pyruvate carrier 1
Mouse	mitochondrial pyruvate carrier 1
Rat	mitochondrial pyruvate carrier 1
Horse	mitochondrial pyruvate carrier 1 [Source:HGNC Symbol;Acc:HGNC:21606]

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q9Y5U8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)

Reactome (4)

WikiPathways (10)

Metabolism (R-HSA-1430728)

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Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Pyruvate metabolism	31 targets	R-HSA-70268
Reactome	Pyruvate metabolism and Citric Acid (TCA) cycle	55 targets	R-HSA-71406
Reactome	The citric acid (TCA) cycle and respiratory electron transport	174 targets	R-HSA-1428517

Name	Explore in Pharos	Explore in Source
Metabolism	2112 targets	R-HSA-1430728
Pyruvate metabolism	31 targets	R-HSA-70268
Pyruvate metabolism and Citric Acid (TCA) cycle	55 targets	R-HSA-71406
The citric acid (TCA) cycle and respiratory electron transport	174 targets	R-HSA-1428517

Gene Ontology Terms (6)

Functions (1)

Components (2)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
pyruvate transmembrane transporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (36)

Explore Interacting Targets

1 – 10 of 36

• See Interactions on String-DB

MPC2

Tbio

Novelty:  0.02948696

p_int:  0.998104717

p_ni:  0.001895281

p_wrong:  1e-9

Score:  0.998

Data Source:  BioPlex,Reactome,STRINGDB

ASS1

Tbio

Family:  Enzyme

Novelty:  0.00358761

p_int:  0.985499765

p_ni:  0.014500235

Data Source:  BioPlex

SRSF5

Tbio

Novelty:  0.01658346

Score:  0.818

Data Source:  STRINGDB

GLB1

Tchem

Family:  Enzyme

Novelty:  0.00241713

Score:  0.641

Data Source:  STRINGDB

PRR18

Tdark

Novelty:  1.18933147

Score:  0.575

Data Source:  STRINGDB

RPS6

Tbio

Novelty:  0.00122241

Score:  0.575

Data Source:  STRINGDB

ITGA5

Tbio

Novelty:  0.00285802

Score:  0.551

Data Source:  STRINGDB

SFT2D1

Tdark

Novelty:  0.56703167

Score:  0.55

Data Source:  STRINGDB

RPS6KA2

Tchem

Family:  Kinase

Novelty:  0.00409407

Score:  0.54

Data Source:  STRINGDB

UQCRFS1

Tbio

Novelty:  0.00341256

Score:  0.538

Data Source:  STRINGDB

Publication Statistics

PubMed Score  89.32

PubMed score by year

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PubTator Score  36.34

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Acetylation
Complete proteome
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Membrane
Mitochondrion
Mitochondrion inner membrane
Polymorphism
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Transmembrane
Transmembrane helix

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cellular phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype