MPC1
Mitochondrial pyruvate carrier 1
Protein Summary
Mediates the uptake of pyruvate into mitochondria. The protein encoded by this gene is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate into mitochondria. The encoded protein is found in the inner mitochondrial membrane. Defects in this gene are a cause of mitochondrial pyruvate carrier deficiency. Several transcript variants, some protein coding and one non-protein coding, have been found for this gene. [provided by RefSeq, Aug 2012]
- ENST00000360961
- ENSP00000354223
- ENSG00000060762
- BRP44L
- MPYCD
- BRP44L
- CGI-129
- SLC54A1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.93 | ||
transcription factor perturbation | 0.91 | ||
histone modification site profile | 0.89 | ||
kinase perturbation | 0.81 | ||
transcription factor binding site profile | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 89.32 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 127 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 89.32 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 127 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (36)
Nearest Tclin Targets
Pathways (14)
Reactome (4)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Pyruvate metabolism | ||||
Reactome | Pyruvate metabolism and Citric Acid (TCA) cycle | ||||
Reactome | The citric acid (TCA) cycle and respiratory electron transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Pyruvate metabolism | ||||
Pyruvate metabolism and Citric Acid (TCA) cycle | ||||
The citric acid (TCA) cycle and respiratory electron transport | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (1)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | mitochondrial pyruvate carrier 1 | VGNC:3488 | 737234 | |||||
Macaque | mitochondrial pyruvate carrier 1 | 716864 | ||||||
Mouse | MGI:1915240 | 55951 | ||||||
Rat | RGD:620902 | 171087 | ||||||
Horse | mitochondrial pyruvate carrier 1 [Source:HGNC Symbol;Acc:HGNC:21606] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | mitochondrial pyruvate carrier 1 | |||||
Macaque | mitochondrial pyruvate carrier 1 | |||||
Mouse | ||||||
Rat | ||||||
Horse | mitochondrial pyruvate carrier 1 [Source:HGNC Symbol;Acc:HGNC:21606] | |||||
Publication Statistics
PubMed Score 89.32
PubMed score by year
PubTator Score 36.34
PubTator score by year
Related Publications
Text Mined References (19)
GeneRif Annotations (12)
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