Tbio TNFRSF18 Tumor necrosis factor receptor superfamily member 18

Protein Summary

Description

Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• Q9Y5U5
• B1AME1
• O95851
• Q5U0I4
• Q9NYJ9

Gene Name

• TNFRSF18

Ensembl ID

• ENST00000328596
• ENSP00000328207
• ENSG00000186891
• ENST00000379265
• ENSP00000368567
• ENST00000379268
• ENSP00000368570

Symbol

• AITR
• GITR
• AITR
• GITR
• CD357
• GITR-D

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.73
interacting protein	0.58
disease	0.54
transcription factor	0.54
biological term	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 288.31   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 812   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 288.31   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 812   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0