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Tbio
TNFRSF18
Tumor necrosis factor receptor superfamily member 18

Protein Summary
Description
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328596
  • ENSP00000328207
  • ENSG00000186891
  • ENST00000379265
  • ENSP00000368567
  • ENST00000379268
  • ENSP00000368570

Symbol
  • AITR
  • GITR
  • AITR
  • GITR
  • CD357
  • GITR-D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
interacting protein
0.58
disease
0.54
transcription factor
0.54
biological term
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 258.89   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 812   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 258.89   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 812   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
TNFSF18
Tbio
Novelty:  0.01423949
Score:  0.994
Data Source:  Reactome,STRINGDB
FOXP3
Tbio
Family:  TF
Novelty:  0.00017205
Score:  0.993
Data Source:  STRINGDB
RUNX1
Tbio
Family:  TF
Novelty:  0.0085181
Score:  0.925
Data Source:  STRINGDB
CTLA4
Tclin
Novelty:  0.00012781
Score:  0.918
Data Source:  STRINGDB
CBFB
Tchem
Family:  TF
Novelty:  0.04825679
Score:  0.9
Data Source:  STRINGDB
TNFRSF4
Tchem
Novelty:  0.0022254
Score:  0.857
Data Source:  STRINGDB
CD28
Tbio
Novelty:  0.00036482
Score:  0.783
Data Source:  STRINGDB
TNFRSF9
Tbio
Novelty:  0.00162382
Score:  0.745
Data Source:  STRINGDB
LAG3
Tbio
Novelty:  0.00187736
Score:  0.742
Data Source:  STRINGDB
ITGAE
Tbio
Novelty:  0.00179591
Score:  0.719
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
1
1
1
21.3
urate measurement
2
1
2
12.2
hair color
1
1
0
1.1
8.6
Thyroid preparation use measurement
1
1
1
4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
1
21.3
urate measurement
2
12.2
hair color
0
1.1
8.6
Thyroid preparation use measurement
1
4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 18
VGNC:11938
741567
Macaque
TNF receptor superfamily member 18
699559
Mouse
MGI:894675
21936
Rat
RGD:1565872
500598
Dog
TNF receptor superfamily member 18
VGNC:47660
606971
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 18
Macaque
TNF receptor superfamily member 18
Mouse
Rat
Dog
TNF receptor superfamily member 18
Publication Statistics
PubMed Score 258.89
PubMed score by year
PubTator Score 160.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title