Protein Summary
NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
- ENST00000217885
- ENSP00000217885
- ENSG00000007952
- ENST00000372966
- ENSP00000362057
- MOX1
- NOH1
- MOX1
- NOH1
- NOH-1
- GP91-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.99 | ||
biological process | 0.97 | ||
biological term | 0.94 | ||
protein domain | 0.92 | ||
virus perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 629.9 (req: < 5)
Gene RIFs: 169 (req: <= 3)
Antibodies: 324 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 629.9 (req: >= 5)
Gene RIFs: 169 (req: > 3)
Antibodies: 324 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 61
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (61)
Protein-Protein Interactions (103)
PPP2R3B
Family: Enzyme
Novelty: 0.02932064
p_int: 0.908383506
p_ni: 0.091407901
p_wrong: 0.000208594
Score: 0.252
Data Source: BioPlex,STRINGDB
RHBDD1
Family: Enzyme
Novelty: 0.10354568
p_int: 0.75300899
p_ni: 0.244182024
p_wrong: 0.002808986
Score: 0.417
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (93)
Reactome (4)
KEGG (3)
PathwayCommons (1)
WikiPathways (85)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | RHO GTPase Effectors | ||||
Reactome | RHO GTPases Activate NADPH Oxidases | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Rho GTPases | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
RHO GTPase Effectors | ||||
RHO GTPases Activate NADPH Oxidases | ||||
Signal Transduction | ||||
Signaling by Rho GTPases | ||||
Viral Interactions (0)
Gene Ontology Terms (33)
Functions (5)
Components (5)
Processes (23)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred by Curator (IC) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | NADPH oxidase 1 | 701376 | ||||||
Mouse | MGI:2450016 | 237038 | ||||||
Rat | RGD:620598 | 114243 | ||||||
Dog | NADPH oxidase 1 | VGNC:43903 | 492016 | |||||
Horse | NADPH oxidase 1 | VGNC:20822 | 100146916 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | NADPH oxidase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | NADPH oxidase 1 | |||||
Horse | NADPH oxidase 1 | |||||
Publication Statistics
PubMed Score 629.90
PubMed score by year
PubTator Score 281.10
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (183)
GeneRif Annotations (169)
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