Tchem NOX1 NADPH oxidase 1

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxidase / Nadph Oxidase 1

Protein Summary

Description

NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

Uniprot Accession IDs

• Q9Y5S8
• A8K836
• O95691
• Q2PP02
• NOX-1

Gene Name

• NOX1

Ensembl ID

• ENST00000217885
• ENSP00000217885
• ENSG00000007952
• ENST00000372966
• ENSP00000362057

Symbol

• MOX1
• NOH1
• MOX1
• NOH1
• NOH-1
• GP91-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
biological process	0.97
biological term	0.94
protein domain	0.92
virus perturbation	0.79

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 629.9   (req: < 5)

Gene RIFs: 169   (req: <= 3)

Antibodies: 324   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 629.9   (req: >= 5)

Gene RIFs: 169   (req: > 3)

Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 61

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (61)

Explore Active Ligands

1 – 10 of 61

Phenothiazine

NOX1Tchem Enzyme

IC50 : 6.46

CHEMBL1927147

NOX1Tchem Enzyme

Ki : 7

GKT137831

NOX1Tchem Enzyme

Ki : 6.8499999

NSC 780521

NOX1Tchem Enzyme

IC50 : 5.98999977

CHEMBL1927146

NOX1Tchem Enzyme

Ki : 6.92

CHEMBL1927160

NOX1Tchem Enzyme

Ki : 6.76

CHEMBL1927158

NOX1Tchem Enzyme

Ki : 6.66

CHEMBL1927148

NOX1Tchem Enzyme

Ki : 6.66

CHEMBL1927154

NOX1Tchem Enzyme

Ki : 6.74

CHEMBL1927159

NOX1Tchem Enzyme

Ki : 6.67

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	NADPH oxidase 1		701376
Mouse	NADPH oxidase 1	MGI:2450016	237038
Rat	NADPH oxidase 1	RGD:620598	114243
Dog	NADPH oxidase 1	VGNC:43903	492016
Horse	NADPH oxidase 1	VGNC:20822	100146916

Species	Name	OMA	EggNOG	Inparanoid
Macaque	NADPH oxidase 1
Mouse	NADPH oxidase 1
Rat	NADPH oxidase 1
Dog	NADPH oxidase 1
Horse	NADPH oxidase 1

Protein Structure (0 Structures, 1 AlphaFold Model)

tutorial

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q9Y5S8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (93)

Reactome (4)

KEGG (3)

PathwayCommons (1)

WikiPathways (85)

RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	RHO GTPase Effectors	273 targets	R-HSA-195258
Reactome	RHO GTPases Activate NADPH Oxidases	24 targets	R-HSA-5668599
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by Rho GTPases	402 targets	R-HSA-194315

Name	Explore in Pharos	Explore in Source
RHO GTPase Effectors	273 targets	R-HSA-195258
RHO GTPases Activate NADPH Oxidases	24 targets	R-HSA-5668599
Signal Transduction	2704 targets	R-HSA-162582
Signaling by Rho GTPases	402 targets	R-HSA-194315

Gene Ontology Terms (33)

Functions (5)

Components (5)

Processes (23)

Find Similar Targets

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
Rac GTPase binding	Inferred from Physical Interaction (IPI)	BHF-UCL
superoxide-generating NADPH oxidase activity	Inferred from Mutant Phenotype (IMP)	BHF-UCL
NADP binding	Inferred by Curator (IC)	BHF-UCL
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
voltage-gated ion channel activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (103)

Explore Interacting Targets

1 – 10 of 103

• See Interactions on String-DB

PPP2R3B

Tbio

Family:  Enzyme

Novelty:  0.02932064

p_int:  0.908383506

p_ni:  0.091407901

p_wrong:  0.000208594

Score:  0.252

Data Source:  BioPlex,STRINGDB

RHBDD1

Tbio

Family:  Enzyme

Novelty:  0.10354568

p_int:  0.75300899

p_ni:  0.244182024

p_wrong:  0.002808986

Score:  0.417

Data Source:  BioPlex,STRINGDB

CYBA

Tbio

Novelty:  0.00177762

Score:  0.996

Data Source:  Reactome,STRINGDB

NOXA1

Tbio

Family:  Enzyme

Novelty:  0.03052419

Score:  0.993

Data Source:  Reactome,STRINGDB

NOXO1

Tbio

Family:  Enzyme

Novelty:  0.02648748

Score:  0.986

Data Source:  Reactome,STRINGDB

NCF1

Tbio

Novelty:  0.00120288

Score:  0.986

Data Source:  STRINGDB

NCF2

Tbio

Novelty:  0.00274685

Score:  0.977

Data Source:  STRINGDB

NCF4

Tbio

Novelty:  0.00560244

Score:  0.946

Data Source:  STRINGDB

DECR1

Tbio

Family:  Enzyme

Novelty:  0.02699187

Score:  0.939

Data Source:  STRINGDB

RAC1

Tbio

Family:  Enzyme

Novelty:  0.00365325

Score:  0.935

Data Source:  Reactome,STRINGDB

Publication Statistics

PubMed Score  629.90

PubMed score by year

Reset Zoom

PubTator Score  281.1

PubTator score by year

Reset Zoom

Patents

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell junction
Cell membrane
Cell projection
Complete proteome
Electron transport
FAD
Flavoprotein
Glycoprotein
Heme

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
digestive/alimentary phenotype
homeostasis/metabolism phenotype
immune system phenotype
muscle phenotype