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Tchem
NOX1
NADPH oxidase 1

Protein Summary
Description
NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217885
  • ENSP00000217885
  • ENSG00000007952
  • ENST00000372966
  • ENSP00000362057

Symbol
  • MOX1
  • NOH1
  • MOX1
  • NOH1
  • NOH-1
  • GP91-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
biological process
0.97
biological term
0.94
protein domain
0.92
virus perturbation
0.79


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 611.74   (req: < 5)
View Publications
Gene RIFs: 169   (req: <= 3)
View Gene RIFs
Antibodies: 324   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 611.74   (req: >= 5)
Gene RIFs: 169   (req: > 3)
Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Explore Active Ligands
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
NADPH oxidase 1
701376
Mouse
NADPH oxidase 1
MGI:2450016
237038
Rat
NADPH oxidase 1
RGD:620598
114243
Dog
NADPH oxidase 1
VGNC:43903
492016
Horse
NADPH oxidase 1
VGNC:20822
100146916
Species
Name
OMA
EggNOG
Inparanoid
Macaque
NADPH oxidase 1
Mouse
NADPH oxidase 1
Rat
NADPH oxidase 1
Dog
NADPH oxidase 1
Horse
NADPH oxidase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y5S8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (93)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
273 targets
R-HSA-195258
Reactome
RHO GTPases Activate NADPH Oxidases
24 targets
R-HSA-5668599
Reactome
Signal Transduction
2704 targets
R-HSA-162582
Reactome
Signaling by Rho GTPases
402 targets
R-HSA-194315
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
273 targets
R-HSA-195258
RHO GTPases Activate NADPH Oxidases
24 targets
R-HSA-5668599
Signal Transduction
2704 targets
R-HSA-162582
Signaling by Rho GTPases
402 targets
R-HSA-194315
Gene Ontology Terms (33)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Rac GTPase binding
Inferred from Physical Interaction (IPI)
BHF-UCL
superoxide-generating NADPH oxidase activity
Inferred from Mutant Phenotype (IMP)
BHF-UCL
NADP binding
Inferred by Curator (IC)
BHF-UCL
metal ion binding
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
voltage-gated ion channel activity
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (103)
1 – 10 of 103
PPP2R3B
Tbio
Family: Enzyme
Novelty: 0.02932064
p_int: 0.908383506
p_ni: 0.091407901
p_wrong: 0.000208594
Score: 0.252
Data Source: BioPlex,STRINGDB
RHBDD1
Tbio
Family: Enzyme
Novelty: 0.10354568
p_int: 0.75300899
p_ni: 0.244182024
p_wrong: 0.002808986
Score: 0.417
Data Source: BioPlex,STRINGDB
CYBA
Tbio
Novelty: 0.00177762
Score: 0.996
Data Source: Reactome,STRINGDB
NOXA1
Tbio
Family: Enzyme
Novelty: 0.03052419
Score: 0.993
Data Source: Reactome,STRINGDB
NOXO1
Tbio
Family: Enzyme
Novelty: 0.02648748
Score: 0.986
Data Source: Reactome,STRINGDB
NCF1
Tbio
Novelty: 0.00120288
Score: 0.986
Data Source: STRINGDB
NCF2
Tbio
Novelty: 0.00274685
Score: 0.977
Data Source: STRINGDB
NCF4
Tbio
Novelty: 0.00560244
Score: 0.946
Data Source: STRINGDB
DECR1
Tbio
Family: Enzyme
Novelty: 0.02699187
Score: 0.939
Data Source: STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.935
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  611.74

PubMed score by year
PubTator Score  281.1

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer