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Tchem
CDC42BPB
Serine/threonine-protein kinase MRCK beta

Protein Summary
Description
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-relate ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361246
  • ENSP00000355237
  • ENSG00000198752

Symbol
  • KIAA1124
  • MRCKB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
interacting protein
0.9
histone modification site profile
0.83
metabolite
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.42   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.42   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (37)
LURAP1L
Tdark
Novelty:  2.32630524
p_int:  0.999999622
p_ni:  3.78e-7
Score:  0.274
Data Source:  BioPlex,STRINGDB
UBXN2B
Tbio
Novelty:  0.67291382
p_int:  0.999996665
p_ni:  0.000003335
Score:  0.6
Data Source:  BioPlex,STRINGDB
FAM167A
Tbio
Novelty:  0.05232679
p_int:  0.999992419
p_ni:  0.000007581
Score:  0.188
Data Source:  BioPlex,STRINGDB
INKA2
Tdark
Novelty:  0.57898295
p_int:  0.999857487
p_ni:  0.000142513
Score:  0.309
Data Source:  BioPlex,STRINGDB
GRPR
Tchem
Family:  GPCR
Novelty:  0.00282511
p_int:  0.995706974
p_ni:  0.004293026
Score:  0.156
Data Source:  BioPlex,STRINGDB
PRKCZ
Tchem
Family:  Kinase
Novelty:  0.00201366
p_int:  0.986977157
p_ni:  0.013022843
Score:  0.21
Data Source:  BioPlex,STRINGDB
TTC9C
Tdark
Novelty:  0.85949913
p_int:  0.927299189
p_ni:  0.072700811
Data Source:  BioPlex
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.92691836
p_ni:  0.07308164
Score:  0.171
Data Source:  BioPlex,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.716
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
6
21
21
6.3
99.9
mean platelet volume
4
8
8
99.6
platelet count
4
5
4
3.5
98.3
serum non-albumin protein measurement
1
4
4
93.2
lymphocyte count
3
3
3
92.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
21
6.3
99.9
mean platelet volume
8
99.6
platelet count
4
3.5
98.3
serum non-albumin protein measurement
4
93.2
lymphocyte count
3
92.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
CDC42 binding protein kinase beta
695720
Mouse
MGI:2136459
217866
Rat
RGD:621753
113960
Dog
CDC42 binding protein kinase beta
VGNC:38998
490868
Horse
CDC42 binding protein kinase beta
VGNC:16297
100058888
Species
Name
OMA
EggNOG
Inparanoid
Macaque
CDC42 binding protein kinase beta
Mouse
Rat
Dog
CDC42 binding protein kinase beta
Horse
CDC42 binding protein kinase beta
Publication Statistics
PubMed Score 7.42
PubMed score by year
PubTator Score 9.17
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title