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Tbio
CDC42BPB
Serine/threonine-protein kinase MRCK beta

Protein Summary
Description
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-relate ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361246
  • ENSP00000355237
  • ENSG00000198752

Symbol
  • KIAA1124
  • MRCKB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
interacting protein
0.9
histone modification site profile
0.83
metabolite
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.05   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.05   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (22)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (37)
1 – 10 of 37
LURAP1L
Tdark
Novelty: 3
p_int: 0.999999622
p_ni: 3.78e-7
Score: 0.274
Data Source: BioPlex,STRINGDB
UBXN2B
Tbio
Novelty: 1.71428571
p_int: 0.999996665
p_ni: 0.000003335
Score: 0.6
Data Source: BioPlex,STRINGDB
FAM167A
Tbio
Novelty: 0.07526216
p_int: 0.999992419
p_ni: 0.000007581
Score: 0.188
Data Source: BioPlex,STRINGDB
INKA2
Tdark
Novelty: 0.85714286
p_int: 0.999857487
p_ni: 0.000142513
Score: 0.309
Data Source: BioPlex,STRINGDB
GRPR
Tchem
Family: GPCR
Novelty: 0.00322431
p_int: 0.995706974
p_ni: 0.004293026
Score: 0.156
Data Source: BioPlex,STRINGDB
PRKCZ
Tchem
Family: Kinase
Novelty: 0.00267081
p_int: 0.986977157
p_ni: 0.013022843
Score: 0.21
Data Source: BioPlex,STRINGDB
TTC9C
Tdark
Novelty: 10
p_int: 0.927299189
p_ni: 0.072700811
Data Source: BioPlex
CSNK2B
Tbio
Family: Kinase
Novelty: 0.00171173
p_int: 0.92691836
p_ni: 0.07308164
Score: 0.171
Data Source: BioPlex,STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00617757
Score: 0.98
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00039759
Score: 0.716
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.05

PubMed score by year
PubTator Score  9.17

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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