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Tbio
DMRT1
Doublesex- and mab-3-related transcription factor 1

Protein Summary
Description
Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity). This gene is found in a cluster with two other members of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382276
  • ENSP00000371711
  • ENSG00000137090

Symbol
  • DMT1
  • DMT1
  • CT154
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
trait
0.86
molecular function
0.84
PubMedID
0.67
gene perturbation
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 269.57   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 278   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 269.57   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
0
1.5
98.7
2
3
0
1.5
94.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
98.7
0
1.5
94.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
doublesex and mab-3 related transcription factor 1
VGNC:4674
473158
Mouse
MGI:1354733
50796
Rat
RGD:621640
114498
Dog
doublesex and mab-3 related transcription factor 1
VGNC:40002
609186
Cow
doublesex and mab-3 related transcription factor 1
VGNC:28110
616245
Species
Name
OMA
EggNOG
Inparanoid
Chimp
doublesex and mab-3 related transcription factor 1
Mouse
Rat
Dog
doublesex and mab-3 related transcription factor 1
Cow
doublesex and mab-3 related transcription factor 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y5R6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (28)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (92)
1 – 10 of 92
AMH
Tbio
Novelty: 0.00022501
Score: 0.897
Data Source: STRINGDB
FOXL2
Tbio
Family: TF
Novelty: 0.00224046
Score: 0.888
Data Source: STRINGDB
KANK1
Tbio
Novelty: 0.02077359
Score: 0.811
Data Source: STRINGDB
STRA8
Tbio
Novelty: 0.00850797
Score: 0.797
Data Source: STRINGDB
CYP19A1
Tclin
Family: Enzyme
Novelty: 0.0003187
Score: 0.79
Data Source: STRINGDB
SOX9
Tbio
Family: TF
Novelty: 0.00047439
Score: 0.777
Data Source: STRINGDB
SOX3
Tbio
Family: TF
Novelty: 0.00280653
Score: 0.767
Data Source: STRINGDB
WNT4
Tbio
Novelty: 0.00276803
Score: 0.763
Data Source: STRINGDB
DOCK8
Tbio
Novelty: 0.0067047
Score: 0.757
Data Source: STRINGDB
NANOS3
Tbio
Novelty: 0.02275038
Score: 0.743
Data Source: STRINGDB
Publication Statistics
PubMed Score  269.57

PubMed score by year
PubTator Score  198.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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