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Tbio
DMRT2
Doublesex- and mab-3-related transcription factor 2

Protein Summary
Description
Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity). The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila 'doublesex' (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. [provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259622
  • ENSP00000259622
  • ENSG00000173253
  • ENST00000358146
  • ENSP00000350865
  • ENST00000382251
  • ENSP00000371686
  • ENST00000382255
  • ENSP00000371690
  • ENST00000412350
  • ENSP00000397494
  • ENST00000635183
  • ENSP00000489226

Symbol
  • DSXL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
gene perturbation
0.71
cell type or tissue
0.64
PubMedID
0.64
cell line
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.28   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.28   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (31)
1 – 10 of 31
FOXL2
Tbio
Family:  TF
Novelty:  0.00224046
Score:  0.746
Data Source:  STRINGDB
TERF1
Tbio
Family:  TF
Novelty:  0.00174529
Score:  0.625
Data Source:  STRINGDB
YIPF5
Tbio
Novelty:  0.08206828
Score:  0.609
Data Source:  STRINGDB
WNT4
Tbio
Novelty:  0.00276803
Score:  0.565
Data Source:  STRINGDB
ZNF142
Tdark
Family:  TF
Novelty:  0.46019293
Score:  0.56
Data Source:  STRINGDB
FXR1
Tbio
Novelty:  0.01279428
Score:  0.558
Data Source:  STRINGDB
TERT
Tchem
Family:  Enzyme
Novelty:  0.00024411
Score:  0.544
Data Source:  STRINGDB
HNRNPA1
Tchem
Novelty:  0.0020871
Score:  0.535
Data Source:  STRINGDB
HNRNPA1L2
Tdark
Novelty:  0.46233313
Score:  0.535
Data Source:  STRINGDB
DNAH6
Tdark
Novelty:  0.18343511
Score:  0.528
Data Source:  STRINGDB
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
70
3
3
2
1
64
hip circumference
1
2
2
55.8
reticulocyte count
1
1
1
40.7
synophrys measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
70
2
1
64
hip circumference
2
55.8
reticulocyte count
1
40.7
synophrys measurement
1
35
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
doublesex and mab-3 related transcription factor 2
VGNC:4675
473159
Macaque
doublesex and mab-3 related transcription factor 2
697088
Mouse
MGI:1330307
226049
Rat
RGD:1309047
309430
Dog
doublesex and mab-3 related transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:2935]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
doublesex and mab-3 related transcription factor 2
Macaque
doublesex and mab-3 related transcription factor 2
Mouse
Rat
Dog
doublesex and mab-3 related transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:2935]
Publication Statistics
PubMed Score 23.28
PubMed score by year
PubTator Score 11.58
PubTator score by year