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Tbio
MMP24
Matrix metalloproteinase-24

Protein Summary
Description
Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity). This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246186
  • ENSP00000246186
  • ENSG00000125966

Symbol
  • MT5MMP
  • MMP25
  • MMP-24
  • MT5MMP
  • MTMMP5
  • MT-MMP5
  • MT5-MMP
  • MT-MMP 5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
disease perturbation
0.93
molecular function
0.73
histone modification site profile
0.67
cellular component
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.93   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.93   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
TIMP2
Tbio
Family:  Enzyme
Novelty:  0.00064016
Score:  0.957
Data Source:  STRINGDB
FURIN
Tchem
Family:  Enzyme
Novelty:  0.00055079
Score:  0.943
Data Source:  STRINGDB
MMP14
Tchem
Family:  Enzyme
Novelty:  0.00083836
Score:  0.904
Data Source:  STRINGDB
TIMP1
Tbio
Family:  Enzyme
Novelty:  0.00020986
Score:  0.642
Data Source:  STRINGDB
TIMP3
Tbio
Family:  Enzyme
Novelty:  0.00134742
Score:  0.639
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.594
Data Source:  STRINGDB
IL21
Tbio
Novelty:  0.00396187
Score:  0.576
Data Source:  STRINGDB
TIMP4
Tbio
Family:  Enzyme
Novelty:  0.006231
Score:  0.566
Data Source:  STRINGDB
ACAN
Tbio
Novelty:  0.00033695
Score:  0.561
Data Source:  STRINGDB
CNDP2
Tbio
Family:  Enzyme
Novelty:  0.00157228
Score:  0.55
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Degradation of the extracellular matrix
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
11
22
99.7
BMI-adjusted hip circumference
2
19
21
97.9
4
5
2
1.1
94.7
body height
6
4
8
93.7
protein C measurement
2
2
2
91.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
22
99.7
BMI-adjusted hip circumference
21
97.9
2
1.1
94.7
body height
8
93.7
protein C measurement
2
91.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 24
VGNC:6190
469925
Macaque
matrix metallopeptidase 24
712005
Mouse
MGI:1341867
17391
Rat
RGD:620202
83513
Dog
matrix metallopeptidase 24
VGNC:43283
485849
Species
Name
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 24
Macaque
matrix metallopeptidase 24
Mouse
Rat
Dog
matrix metallopeptidase 24
Publication Statistics
PubMed Score 38.93
PubMed score by year
PubTator Score 14.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title