Tdark GTF3C5 General transcription factor 3C polypeptide 5

Protein Summary

Description

Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

Uniprot Accession IDs

• Q9Y5Q8
• A6NI44
• A6NJB9
• Q5T7U2
• Q5T7U3
• Q8N2U7
• Q8N857
• Q96GD9
• Q9H4P2

Gene Name

• GTF3C5

Ensembl ID

• ENST00000372097
• ENSP00000361169
• ENSG00000148308
• ENST00000372108
• ENSP00000361180

Symbol

• TFIIIC63
• TFiiiC2-63
• TFIIICepsilon

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.83
protein complex	0.83
transcription factor binding site profile	0.81
small molecule perturbation	0.7
cell type or tissue	0.66

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / General Transcription Factor 3c Polypeptide 5

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / General Transcription Factor 3c Polypeptide 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.3   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 185   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.3   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0