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Tbio
MAFB
Transcription factor MafB

Protein Summary
Description
Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373313
  • ENSP00000362410
  • ENSG00000204103

Symbol
  • KRML
  • KRML
  • MCTO
  • DURS3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
0.98
small molecule perturbation
0.92
transcription factor perturbation
0.88
transcription factor binding site profile
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.07   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.07   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (140)
HOXB1
Tbio
Family:  TF
Novelty:  0.00731831
Score:  0.967
Data Source:  STRINGDB
JUN
Tchem
Family:  TF
Novelty:  0.00006856
Score:  0.966
Data Source:  Reactome,STRINGDB
EGR2
Tbio
Family:  TF
Novelty:  0.00215433
Score:  0.96
Data Source:  STRINGDB
RBBP5
Tbio
Novelty:  0.02221059
Score:  0.945
Data Source:  STRINGDB
HOXB3
Tbio
Family:  TF
Novelty:  0.01572964
Score:  0.94
Data Source:  STRINGDB
KDM6A
Tchem
Family:  Epigenetic
Novelty:  0.00267001
Score:  0.935
Data Source:  STRINGDB
NCOA6
Tbio
Novelty:  0.00750424
Score:  0.932
Data Source:  STRINGDB
HOXA3
Tbio
Family:  TF
Novelty:  0.01407069
Score:  0.926
Data Source:  STRINGDB
PKNOX1
Tbio
Family:  TF
Novelty:  0.01063674
Score:  0.916
Data Source:  STRINGDB
CTCF
Tbio
Family:  TF
Novelty:  0.00085923
Score:  0.915
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Developmental Biology
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
3
4
82.8
total cholesterol measurement
1
3
3
82
5
5
0
1.4
81.2
apolipoprotein B measurement
1
2
2
78.1
lymphocyte count
2
3
3
76.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
82.8
total cholesterol measurement
3
82
0
1.4
81.2
apolipoprotein B measurement
2
78.1
lymphocyte count
3
76.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MAF bZIP transcription factor B
VGNC:14257
469941
Mouse
MGI:104555
16658
Rat
RGD:2982
54264
Horse
MAF bZIP transcription factor B
VGNC:51571
100055709
Cow
MAF bZIP transcription factor B
VGNC:31139
532376
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MAF bZIP transcription factor B
Mouse
Rat
Horse
MAF bZIP transcription factor B
Cow
MAF bZIP transcription factor B
Publication Statistics
PubMed Score 159.07
PubMed score by year
PubTator Score 91.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title