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Tbio
PPP2R3B
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

Protein Summary
Description
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. [provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000390665
  • ENSP00000375080
  • ENSG00000167393

Symbol
  • PPP2R3L
  • PR48
  • PR70
  • NYREN8
  • PPP2R3L
  • PPP2R3LY
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.72
cell line
0.63
histone modification site profile
0.57
small molecule perturbation
0.57
tissue sample
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.65   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.65   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (34)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A/B1/B2 associated events during G2/M transition
Reactome
Cyclin D associated events in G1
Reactome
E2F mediated regulation of DNA replication
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin D associated events in G1
E2F mediated regulation of DNA replication
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (111)
1 – 10 of 111
TBCCD1
Tbio
Novelty: 0.21991508
p_int: 0.999999996
p_ni: 3e-9
p_wrong: 1e-9
Score: 0.811
Data Source: BioPlex,STRINGDB
PPP2R1A
Tbio
Family: Enzyme
Novelty: 0.01134139
p_int: 0.999999747
p_ni: 2.53e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
PPP2CB
Tbio
Family: Enzyme
Novelty: 0.0483178
p_int: 0.999999488
p_ni: 5.12e-7
Score: 0.967
Data Source: BioPlex,STRINGDB
CCDC9
Tdark
Novelty: 0.73149492
p_int: 0.999973041
p_ni: 0.000026958
p_wrong: 1e-9
Data Source: BioPlex
KRBA1
Tdark
Novelty: 2.59384945
p_int: 0.999858986
p_ni: 0.000140999
p_wrong: 1.6e-8
Score: 0.54
Data Source: BioPlex,STRINGDB
RNF10
Tbio
Novelty: 0.09086567
p_int: 0.999828011
p_ni: 0.000171936
p_wrong: 5.3e-8
Data Source: BioPlex
INAVA
Tbio
Novelty: 0.19311978
p_int: 0.999593619
p_ni: 0.00040638
Score: 0.181
Data Source: BioPlex,STRINGDB
GPR156
Tdark
Family: GPCR
Novelty: 0.39183023
p_int: 0.999554495
p_ni: 0.000445504
p_wrong: 1e-9
Data Source: BioPlex
ZNF414
Tdark
Novelty: 1.29024829
p_int: 0.998898952
p_ni: 0.001101033
p_wrong: 1.5e-8
Data Source: BioPlex
NOX1
Tchem
Family: Enzyme
Novelty: 0.0016839
p_int: 0.908383506
p_ni: 0.091407901
p_wrong: 0.000208594
Score: 0.252
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  34.65

PubMed score by year
PubTator Score  20.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer