Tbio GMPPB Mannose-1-phosphate guanyltransferase beta

Protein Summary

Description

Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. This gene is thought to encode a GDP-mannose pyrophosphorylase. The encoded protein catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, a reaction involved in the production of N-linked oligosaccharides. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2009]

Uniprot Accession IDs

• Q9Y5P6
• A8K6N5
• Q9H7U3

Gene Name

• GMPPB

Ensembl ID

• ENST00000308375
• ENSP00000309092
• ENSG00000173540
• ENST00000308388
• ENSP00000311130
• ENST00000480687
• ENSP00000418565

Symbol

• LGMDR19
• MDDGA14
• MDDGB14
• MDDGC14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.91
histone modification site profile	0.86
phenotype	0.73
transcription factor perturbation	0.68
transcription factor	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.91   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 153   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.91   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0