Tbio COL4A3BP Collagen type IV alpha-3-binding protein

Protein Summary

Description

Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y5P4
• A8K7S2
• B3KUB7
• Q53YV1
• Q53YV2
• Q96Q85
• Q96Q88
• Q9H2S7
• Q9H2S8

Gene Name

• COL4A3BP

Ensembl ID

• ENST00000261415
• ENSP00000261415
• ENSG00000113163
• ENST00000405807
• ENSP00000383996
• ENST00000643780
• ENSP00000495760
• ENST00000644072
• ENSP00000494110
• ENST00000644445
• ENSP00000496243
• ENST00000645483
• ENSP00000493563
• ENST00000646511
• ENSP00000495446

Symbol

• CERT
• STARD11
• CERT
• GPBP
• CERTL
• MRD34
• STARD11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.83
microRNA	0.79
molecular function	0.79
transcription factor binding site profile	0.79
transcription factor	0.72

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Collagen Type Iv Alpha-3-binding Protein

DTO Classes

Protein / Transporter / Collagen Type Iv Alpha-3-binding Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.65   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 336   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.65   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0