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Tbio
COL4A3BP
Collagen type IV alpha-3-binding protein

Protein Classes
Protein Summary
Description
Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261415
  • ENSP00000261415
  • ENSG00000113163
  • ENST00000405807
  • ENSP00000383996
  • ENST00000643780
  • ENSP00000495760
  • ENST00000644072
  • ENSP00000494110
  • ENST00000644445
  • ENSP00000496243
  • ENST00000645483
  • ENSP00000493563
  • ENST00000646511
  • ENSP00000495446

Symbol
  • CERT
  • STARD11
  • CERT
  • GPBP
  • CERTL
  • MRD34
  • STARD11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
microRNA
0.79
molecular function
0.79
transcription factor binding site profile
0.79
transcription factor
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.04   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 336   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.04   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
9
2
10
3
99
total cholesterol measurement
7
3
8
3.6
98.6
apolipoprotein B measurement
1
1
1
71.3
HMG CoA reductase inhibitor use measurement
1
1
1
54.3
platelet count
1
1
1
41.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
10
3
99
total cholesterol measurement
8
3.6
98.6
apolipoprotein B measurement
1
71.3
HMG CoA reductase inhibitor use measurement
1
54.3
platelet count
1
41.9
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen type IV alpha 3 binding protein
VGNC:6846
471515
Macaque
collagen type IV alpha 3 binding protein
705834
Mouse
MGI:1915268
68018
Rat
RGD:1309131
365652
Dog
collagen type IV alpha 3 binding protein
VGNC:39475
612799
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen type IV alpha 3 binding protein
Macaque
collagen type IV alpha 3 binding protein
Mouse
Rat
Dog
collagen type IV alpha 3 binding protein
Protein Structure (16 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y5P4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 16
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Gene Ontology Terms (31)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (79)
1 – 10 of 79
MARK1
Tchem
Family: Kinase
Novelty: 0.02342173
p_int: 0.999999999
p_ni: 1e-9
Score: 0.269
Data Source: BioPlex,STRINGDB
MARK2
Tchem
Family: Kinase
Novelty: 0.00437762
p_int: 0.999999982
p_ni: 1.8e-8
Score: 0.194
Data Source: BioPlex,STRINGDB
EYA1
Tbio
Novelty: 0.00585286
p_int: 0.999999961
p_ni: 3.7e-8
p_wrong: 2e-9
Score: 0.199
Data Source: BioPlex,STRINGDB
MARK3
Tchem
Family: Kinase
Novelty: 0.01304552
p_int: 0.999999895
p_ni: 1.05e-7
Score: 0.192
Data Source: BioPlex,STRINGDB
TRAF7
Tbio
Family: Enzyme
Novelty: 0.02437761
p_int: 0.999978572
p_ni: 0.000021317
p_wrong: 1.1e-7
Score: 0.159
Data Source: BioPlex,STRINGDB
IFT20
Tbio
Novelty: 0.03005088
p_int: 0.99991302
p_ni: 0.00008698
Data Source: BioPlex
CSNK1G2
Tchem
Family: Kinase
Novelty: 0.17930147
p_int: 0.99834726
p_ni: 0.00165274
p_wrong: 1e-9
Score: 0.584
Data Source: BioPlex,Reactome,STRINGDB
EXOSC3
Tbio
Novelty: 0.03072164
p_int: 0.990243656
p_ni: 0.009756338
p_wrong: 6e-9
Score: 0.28
Data Source: BioPlex,STRINGDB
RUFY1
Tbio
Novelty: 0.16796947
p_int: 0.983123858
p_ni: 0.01687585
p_wrong: 2.92e-7
Score: 0.202
Data Source: BioPlex,STRINGDB
ENTPD7
Tbio
Family: Enzyme
Novelty: 0.1810079
p_int: 0.882062484
p_ni: 0.117936795
p_wrong: 7.2e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  286.04

PubMed score by year
PubTator Score  104.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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