Tbio RAI2 Retinoic acid-induced protein 2

Protein Summary

Description

Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function of this retinoic acid-induced gene has not yet been determined but it may play a role in development. The chromosomal location of this gene designates it to be a candidate for diseases such as Nance-Horan syndrome, sensorineural deafness, non-specific X-linked cognitive disability, oral-facial-digital syndrome, and Fried syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• Q9Y5P3
• B1B1K2
• B4DQM9
• E7EMN4
• Q8N6X7

Gene Name

• RAI2

Ensembl ID

• ENST00000331511
• ENSP00000333456
• ENSG00000131831
• ENST00000360011
• ENSP00000353106
• ENST00000415486
• ENSP00000392578
• ENST00000451717
• ENSP00000401323
• ENST00000545871
• ENSP00000444210

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.85
cell type or tissue	0.78
tissue sample	0.69
small molecule perturbation	0.54
PubMedID	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.05   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 40   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.05   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0