Tbio ORC6 Origin recognition complex subunit 6

Protein Summary

Description

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]

Uniprot Accession IDs

• Q9Y5N6
• B3KN89

Gene Name

• ORC6

Ensembl ID

• ENST00000219097
• ENSP00000219097
• ENSG00000091651

Symbol

• ORC6L
• ORC6L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
histone modification site profile	0.88
transcription factor binding site profile	0.82
hub protein	0.75
disease perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Replication Origin Binding Protein / Origin Recognition Complex Subunit 6

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Replication Origin Binding Protein / Origin Recognition Complex Subunit 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.55   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 215   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.55   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0