Tbio ORC6 Origin recognition complex subunit 6

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Replication Origin Binding Protein / Origin Recognition Complex Subunit 6

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Replication Origin Binding Protein / Origin Recognition Complex Subunit 6

Protein Summary

Description

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]

Uniprot Accession IDs

• Q9Y5N6
• B3KN89

Gene Name

• ORC6

Ensembl ID

• ENST00000219097
• ENSP00000219097
• ENSG00000091651

Symbol

• ORC6L
• ORC6L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
histone modification site profile	0.88
transcription factor binding site profile	0.82
hub protein	0.75
disease perturbation	0.74

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.62   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 215   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.62   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	origin recognition complex subunit 6	VGNC:5860	465140
Macaque	origin recognition complex subunit 6		716175
Mouse	origin recognition complex, subunit 6	MGI:1929285	56452
Rat	origin recognition complex, subunit 6	RGD:1311437	291927
Dog	origin recognition complex subunit 6	VGNC:44145	482492

Species	Name	OMA	EggNOG	Inparanoid
Chimp	origin recognition complex subunit 6
Macaque	origin recognition complex subunit 6
Mouse	origin recognition complex, subunit 6
Rat	origin recognition complex, subunit 6
Dog	origin recognition complex subunit 6

Protein Structure (1 Structure, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y5N6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (24)

Reactome (20)

KEGG (1)

WikiPathways (3)

Activation of ATR in response to replication stress (R-HSA-176187)

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Find Similar Targets

Items per page:

5

1 – 5 of 20

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of ATR in response to replication stress	37 targets	R-HSA-176187
Reactome	Activation of the pre-replicative complex	33 targets	R-HSA-68962
Reactome	Assembly of the ORC complex at the origin of replication	6 targets	R-HSA-68616
Reactome	Assembly of the pre-replicative complex	69 targets	R-HSA-68867
Reactome	CDC6 association with the ORC:origin complex	11 targets	R-HSA-68689

Name	Explore in Pharos	Explore in Source
Activation of ATR in response to replication stress	37 targets	R-HSA-176187
Activation of the pre-replicative complex	33 targets	R-HSA-68962
Assembly of the ORC complex at the origin of replication	6 targets	R-HSA-68616
Assembly of the pre-replicative complex	69 targets	R-HSA-68867
CDC6 association with the ORC:origin complex	11 targets	R-HSA-68689

Gene Ontology Terms (11)

Functions (1)

Components (6)

Processes (4)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
DNA replication origin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (143)

Explore Interacting Targets

1 – 10 of 143

• See Interactions on String-DB

ORC2

Tbio

Novelty: 0.11963517

p_int: 0.999999971

p_ni: 1.5e-8

p_wrong: 1.4e-8

Score: 0.999

Data Source: BioPlex,Reactome,STRINGDB

BICD2

Tbio

Novelty: 0.01725046

p_int: 0.999401281

p_ni: 0.000598585

p_wrong: 1.35e-7

Score: 0.211

Data Source: BioPlex,STRINGDB

LRWD1

Tbio

Novelty: 0.09049722

p_int: 0.996184712

p_ni: 0.003815288

Score: 0.936

Data Source: BioPlex,STRINGDB

DCTN6

Tdark

Novelty: 0.30624393

p_int: 0.97180976

p_ni: 0.028189759

p_wrong: 4.82e-7

Score: 0.186

Data Source: BioPlex,STRINGDB

CREB1

Tbio

Family: TF

Novelty: 0.00018059

p_int: 0.952121796

p_ni: 0.047877071

p_wrong: 0.000001132

Score: 0.163

Data Source: BioPlex,STRINGDB

PPIL4

Tdark

Family: Enzyme

Novelty: 0.3737992

p_int: 0.927516085

p_ni: 0.072454144

p_wrong: 0.000029771

Score: 0.226

Data Source: BioPlex,STRINGDB

PSPC1

Tbio

Novelty: 0.01002246

p_int: 0.921456097

p_ni: 0.078543903

Score: 0.332

Data Source: BioPlex,STRINGDB

CYB5B

Tbio

Novelty: 0.09395308

p_int: 0.794650336

p_ni: 0.000023477

p_wrong: 0.205326187

Data Source: BioPlex

ORC3

Tbio

Novelty: 0.03409802

Score: 0.999

Data Source: Reactome,STRINGDB

MCM7

Tbio

Novelty: 0.0017984

Score: 0.999

Data Source: STRINGDB

Publication Statistics

PubMed Score  41.62

PubMed score by year

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PubTator Score  14.81

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Complete proteome
Disease mutation
DNA replication
DNA-binding
Dwarfism
Isopeptide bond
Nucleus
Phosphoprotein
Polymorphism

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behavior/neurological phenotype
mortality/aging
vision/eye phenotype