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Tbio
ORC6
Origin recognition complex subunit 6

Protein Summary
Description
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219097
  • ENSP00000219097
  • ENSG00000091651

Symbol
  • ORC6L
  • ORC6L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
histone modification site profile
0.88
transcription factor binding site profile
0.82
hub protein
0.75
disease perturbation
0.74


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.62   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.62   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
origin recognition complex subunit 6
VGNC:5860
465140
Macaque
origin recognition complex subunit 6
716175
Mouse
MGI:1929285
56452
Rat
RGD:1311437
291927
Dog
origin recognition complex subunit 6
VGNC:44145
482492
Species
Name
OMA
EggNOG
Inparanoid
Chimp
origin recognition complex subunit 6
Macaque
origin recognition complex subunit 6
Mouse
Rat
Dog
origin recognition complex subunit 6
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y5N6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Assembly of the ORC complex at the origin of replication
Reactome
Assembly of the pre-replicative complex
Reactome
CDC6 association with the ORC:origin complex
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Assembly of the ORC complex at the origin of replication
Assembly of the pre-replicative complex
CDC6 association with the ORC:origin complex
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (143)
1 – 10 of 143
ORC2
Tbio
Novelty: 0.11963517
p_int: 0.999999971
p_ni: 1.5e-8
p_wrong: 1.4e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
BICD2
Tbio
Novelty: 0.01725046
p_int: 0.999401281
p_ni: 0.000598585
p_wrong: 1.35e-7
Score: 0.211
Data Source: BioPlex,STRINGDB
LRWD1
Tbio
Novelty: 0.09049722
p_int: 0.996184712
p_ni: 0.003815288
Score: 0.936
Data Source: BioPlex,STRINGDB
DCTN6
Tdark
Novelty: 0.30624393
p_int: 0.97180976
p_ni: 0.028189759
p_wrong: 4.82e-7
Score: 0.186
Data Source: BioPlex,STRINGDB
CREB1
Tbio
Family: TF
Novelty: 0.00018059
p_int: 0.952121796
p_ni: 0.047877071
p_wrong: 0.000001132
Score: 0.163
Data Source: BioPlex,STRINGDB
PPIL4
Tdark
Family: Enzyme
Novelty: 0.3737992
p_int: 0.927516085
p_ni: 0.072454144
p_wrong: 0.000029771
Score: 0.226
Data Source: BioPlex,STRINGDB
PSPC1
Tbio
Novelty: 0.01002246
p_int: 0.921456097
p_ni: 0.078543903
Score: 0.332
Data Source: BioPlex,STRINGDB
CYB5B
Tbio
Novelty: 0.09395308
p_int: 0.794650336
p_ni: 0.000023477
p_wrong: 0.205326187
Data Source: BioPlex
ORC3
Tbio
Novelty: 0.03409802
Score: 0.999
Data Source: Reactome,STRINGDB
MCM7
Tbio
Novelty: 0.0017984
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  41.62

PubMed score by year
PubTator Score  14.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer