ORC6
Origin recognition complex subunit 6
Protein Summary
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq ...more
- ENST00000219097
- ENSP00000219097
- ENSG00000091651
- ORC6L
- ORC6L
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.93 | ||
histone modification site profile | 0.88 | ||
transcription factor binding site profile | 0.82 | ||
hub protein | 0.75 | ||
disease perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.66 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 215 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.66 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 215 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (143)
ORC2
Novelty: 0.11963517
p_int: 0.999999971
p_ni: 1.5e-8
p_wrong: 1.4e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
BICD2
Novelty: 0.01725046
p_int: 0.999401281
p_ni: 0.000598585
p_wrong: 1.35e-7
Score: 0.211
Data Source: BioPlex,STRINGDB
LRWD1
Novelty: 0.09049722
p_int: 0.996184712
p_ni: 0.003815288
Score: 0.936
Data Source: BioPlex,STRINGDB
DCTN6
Novelty: 0.30624393
p_int: 0.97180976
p_ni: 0.028189759
p_wrong: 4.82e-7
Score: 0.186
Data Source: BioPlex,STRINGDB
CREB1
Family: TF
Novelty: 0.00018059
p_int: 0.952121796
p_ni: 0.047877071
p_wrong: 0.000001132
Score: 0.163
Data Source: BioPlex,STRINGDB
PPIL4
Family: Enzyme
Novelty: 0.3737992
p_int: 0.927516085
p_ni: 0.072454144
p_wrong: 0.000029771
Score: 0.226
Data Source: BioPlex,STRINGDB
PSPC1
Novelty: 0.01002246
p_int: 0.921456097
p_ni: 0.078543903
Score: 0.332
Data Source: BioPlex,STRINGDB
CYB5B
Novelty: 0.09395308
p_int: 0.794650336
p_ni: 0.000023477
p_wrong: 0.205326187
Data Source: BioPlex
Nearest Tclin Targets
Pathways (24)
Reactome (20)
KEGG (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of ATR in response to replication stress | ||||
Reactome | Activation of the pre-replicative complex | ||||
Reactome | Assembly of the ORC complex at the origin of replication | ||||
Reactome | Assembly of the pre-replicative complex | ||||
Reactome | CDC6 association with the ORC:origin complex | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of ATR in response to replication stress | ||||
Activation of the pre-replicative complex | ||||
Assembly of the ORC complex at the origin of replication | ||||
Assembly of the pre-replicative complex | ||||
CDC6 association with the ORC:origin complex | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (1)
Components (6)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | origin recognition complex subunit 6 | VGNC:5860 | 465140 | |||||
Macaque | origin recognition complex subunit 6 | 716175 | ||||||
Mouse | MGI:1929285 | 56452 | ||||||
Rat | RGD:1311437 | 291927 | ||||||
Dog | origin recognition complex subunit 6 | VGNC:44145 | 482492 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | origin recognition complex subunit 6 | |||||
Macaque | origin recognition complex subunit 6 | |||||
Mouse | ||||||
Rat | ||||||
Dog | origin recognition complex subunit 6 | |||||
Publication Statistics
PubMed Score 42.66
PubMed score by year
PubTator Score 14.81
PubTator score by year
Related Publications
Text Mined References (38)
GeneRif Annotations (11)
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