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Tbio
N6AMT1
Methyltransferase N6AMT1

Protein Summary
Description
Methyltransferase that can methylate both proteins and DNA, and to a lower extent, arsenic (PubMed:18539146, PubMed:21193388, PubMed:30017583). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:18539146) (By similarity). Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated (PubMed:18539146, PubMed:20606008). Also acts as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (PubMed:30017583). N(6)-methyladenosine (m6A) DNA is significantly enriched in exonic regions and is associated with gene transcriptional activation (PubMed:30017583). May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (PubMed:21193388, PubMed:25997655). It howev ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303775
  • ENSP00000303584
  • ENSG00000156239
  • ENST00000351429
  • ENSP00000286764
  • ENST00000460212
  • ENSP00000436490

Symbol
  • C21orf127
  • HEMK2
  • PRED28
  • MTQ2
  • HEMK2
  • N6AMT
  • PRED28
  • C21orf127
  • m.HsaHemK2P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor binding site profile
0.79
tissue sample
0.69
transcription factor
0.62
cell type or tissue
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.5   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.5   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (68)
1 – 10 of 68
TRMT112
Tbio
Family:  Enzyme
Novelty:  0.05451623
Score:  0.999
Data Source:  Reactome,STRINGDB
ETF1
Tbio
Family:  Enzyme
Novelty:  0.00711627
Score:  0.987
Data Source:  Reactome,STRINGDB
GSPT1
Tbio
Family:  Enzyme
Novelty:  0.02545195
Score:  0.948
Data Source:  Reactome,STRINGDB
GSPT2
Tchem
Family:  Enzyme
Novelty:  0.08140512
Score:  0.937
Data Source:  Reactome,STRINGDB
ALKBH8
Tbio
Novelty:  0.02797162
Score:  0.912
Data Source:  STRINGDB
BUD23
Tbio
Family:  Enzyme
Novelty:  0.04803274
Score:  0.901
Data Source:  STRINGDB
TRMT11
Tbio
Family:  Enzyme
Novelty:  0.11506701
Score:  0.898
Data Source:  STRINGDB
HEMK1
Tbio
Family:  Enzyme
Novelty:  0.03509926
Score:  0.869
Data Source:  STRINGDB
WDR4
Tbio
Family:  Enzyme
Novelty:  0.06887397
Score:  0.807
Data Source:  STRINGDB
AS3MT
Tbio
Family:  Enzyme
Novelty:  0.00520406
Score:  0.793
Data Source:  STRINGDB
Pathways (7)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Eukaryotic Translation Termination
Reactome
Metabolism
Reactome
Metabolism of proteins
Reactome
Methylation
Name
Explore in Pharos
Explore in Source
Biological oxidations
Eukaryotic Translation Termination
Metabolism
Metabolism of proteins
Methylation
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
1
3
80.9
reticulocyte count
2
1
2
80.2
serum gamma-glutamyl transferase measurement
1
1
1
21.4
serum alanine aminotransferase measurement
1
1
1
8.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
80.9
reticulocyte count
2
80.2
serum gamma-glutamyl transferase measurement
1
21.4
serum alanine aminotransferase measurement
1
8.8
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-6 adenine-specific DNA methyltransferase 1
VGNC:10504
470059
Macaque
N-6 adenine-specific DNA methyltransferase 1
706937
Mouse
MGI:1915018
67768
Rat
RGD:1311843
288309
Horse
N-6 adenine-specific DNA methyltransferase 1
VGNC:50486
100065688
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-6 adenine-specific DNA methyltransferase 1
Macaque
N-6 adenine-specific DNA methyltransferase 1
Mouse
Rat
Horse
N-6 adenine-specific DNA methyltransferase 1
Publication Statistics
PubMed Score 27.50
PubMed score by year
PubTator Score 9.83
PubTator score by year