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Tdark
TIMM13
Mitochondrial import inner membrane translocase subunit Tim13

Protein Summary
Description
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. This gene encodes a member of the evolutionarily conserved TIMM (translocase of inner mitochondrial membrane) family of proteins that function as chaperones in the import of proteins from the cytoplasm into the mitochondrial inner membrane. Proteins of this family play a role in collecting substrate proteins from the trans ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215570
  • ENSP00000215570
  • ENSG00000099800

Symbol
  • TIM13B
  • TIMM13A
  • TIMM13B
  • ppv1
  • TIM13
  • TIM13B
  • TIMM13A
  • TIMM13B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.85
kinase perturbation
0.84
disease perturbation
0.83
histone modification site profile
0.82
transcription factor binding site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.82   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.82   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (177)
1 – 10 of 177
TIMM8A
Tbio
Family:  Enzyme
Novelty:  0.00954602
p_int:  0.995074569
p_ni:  0.004925431
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PDYN
Tbio
Novelty:  0.00039564
p_int:  0.986451582
p_ni:  0.013548418
Score:  0.513
Data Source:  BioPlex,STRINGDB
YBEY
Tdark
Family:  Enzyme
Novelty:  0.02778029
p_int:  0.975214727
p_ni:  0.024785273
Score:  0.188
Data Source:  BioPlex,STRINGDB
VILL
Tbio
Novelty:  0.04080467
p_int:  0.908475132
p_ni:  0.091524868
Score:  0.379
Data Source:  BioPlex,STRINGDB
ZNF385C
Tdark
Novelty:  2.23931637
p_int:  0.830791589
p_ni:  0.169208411
Data Source:  BioPlex
STPG3
Tdark
Novelty:  1.88764045
p_int:  0.828240574
p_ni:  0.171759426
Score:  0.379
Data Source:  BioPlex,STRINGDB
TIMM9
Tbio
Family:  Enzyme
Novelty:  0.02996764
Score:  0.999
Data Source:  STRINGDB
TIMM10
Tbio
Family:  Enzyme
Novelty:  0.02727463
Score:  0.999
Data Source:  STRINGDB
TIMM8B
Tbio
Family:  Enzyme
Novelty:  0.02843625
Score:  0.999
Data Source:  Reactome,STRINGDB
TIMM23
Tbio
Family:  Enzyme
Novelty:  0.06463808
Score:  0.996
Data Source:  STRINGDB
Pathways (2)
Mitochondrial protein import (R-HSA-1268020)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
78.1
age-related hearing impairment
1
1
0
5.9
30.2
mathematical ability
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
78.1
age-related hearing impairment
0
5.9
30.2
mathematical ability
1
28.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
translocase of inner mitochondrial membrane 13
VGNC:8299
468656
Mouse
MGI:1353432
30055
Rat
RGD:628845
252928
Horse
translocase of inner mitochondrial membrane 13
VGNC:50502
100060448
Cow
translocase of inner mitochondrial membrane 13
VGNC:52893
516325
Species
Name
OMA
EggNOG
Inparanoid
Chimp
translocase of inner mitochondrial membrane 13
Mouse
Rat
Horse
translocase of inner mitochondrial membrane 13
Cow
translocase of inner mitochondrial membrane 13
Publication Statistics
PubMed Score 17.82
PubMed score by year
PubTator Score 35.33
PubTator score by year