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Tchem
ENTPD2
Ectonucleoside triphosphate diphosphohydrolase 2

Protein Summary
Description
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP. The protein encoded by this gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312665
  • ENSP00000312494
  • ENSG00000054179
  • ENST00000355097
  • ENSP00000347213

Symbol
  • CD39L1
  • CD39L1
  • NTPDase-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
disease perturbation
0.79
cellular component
0.7
PubMedID
0.66
cell type or tissue
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 750.21   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 750.21   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (131)
AK8
Tbio
Family:  Kinase
Novelty:  0.05983262
Score:  0.937
Data Source:  STRINGDB
AK1
Tbio
Family:  Kinase
Novelty:  0.00268549
Score:  0.937
Data Source:  STRINGDB
NTPCR
Tbio
Family:  Enzyme
Novelty:  0.0638186
Score:  0.93
Data Source:  STRINGDB
PKLR
Tbio
Family:  Kinase
Novelty:  0.00268398
Score:  0.923
Data Source:  STRINGDB
NME3
Tbio
Family:  Kinase
Novelty:  0.05947052
Score:  0.919
Data Source:  STRINGDB
ENTPD8
Tbio
Family:  Enzyme
Novelty:  0.00989166
Score:  0.915
Data Source:  STRINGDB
AK2
Tbio
Family:  Kinase
Novelty:  0.00581034
Score:  0.914
Data Source:  STRINGDB
NME6
Tbio
Family:  Kinase
Novelty:  0.12087274
Score:  0.913
Data Source:  STRINGDB
PKM
Tchem
Family:  Kinase
Novelty:  0.00076567
Score:  0.913
Data Source:  STRINGDB
AK5
Tbio
Family:  Kinase
Novelty:  0.01301579
Score:  0.912
Data Source:  STRINGDB
Pathways (8)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Phosphate bond hydrolysis by NTPDase proteins
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Phosphate bond hydrolysis by NTPDase proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
3
4
91.5
monocyte percentage of leukocytes
2
2
2
88
leukocyte count
2
2
3
70.2
central corneal thickness
3
2
0
2.9
69.8
lymphocyte percentage of leukocytes
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
91.5
monocyte percentage of leukocytes
2
88
leukocyte count
3
70.2
central corneal thickness
0
2.9
69.8
lymphocyte percentage of leukocytes
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ectonucleoside triphosphate diphosphohydrolase 2
VGNC:13876
464883
Macaque
ectonucleoside triphosphate diphosphohydrolase 2
721617
Mouse
MGI:1096863
12496
Rat
RGD:69266
64467
Dog
ectonucleoside triphosphate diphosphohydrolase 2
VGNC:40381
491241
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ectonucleoside triphosphate diphosphohydrolase 2
Macaque
ectonucleoside triphosphate diphosphohydrolase 2
Mouse
Rat
Dog
ectonucleoside triphosphate diphosphohydrolase 2
Publication Statistics
PubMed Score 750.21
PubMed score by year
PubTator Score 31.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title