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Tbio
HILPDA
Hypoxia-inducible lipid droplet-associated protein

Protein Summary
Description
Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257696
  • ENSP00000257696
  • ENSG00000135245
  • ENST00000435296
  • ENSP00000388871

Symbol
  • C7orf68
  • HIG2
  • HIG2
  • HIG-2
  • C7orf68
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
cellular component
0.74
transcription factor binding site profile
0.72
kinase perturbation
0.71
small molecule perturbation
0.67


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.68   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.68   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y5L2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Lipid particle organization (R-HSA-8964572)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Lipid particle organization
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Lipid particle organization
Metabolism
Metabolism of lipids
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (13)
1 – 10 of 13
PNPLA2
Tchem
Family: Enzyme
Novelty: 0.00149181
Score: 0.526
Data Source: STRINGDB
FZD10
Tbio
Family: GPCR
Novelty: 0.02786933
Score: 0.498
Data Source: STRINGDB
EGLN3
Tclin
Novelty: 0.00643992
Score: 0.494
Data Source: STRINGDB
C2orf27B
Tdark
Novelty: 4.24242424
Score: 0.479
Data Source: STRINGDB
PLEKHF1
Tbio
Novelty: 0.02694931
Score: 0.475
Data Source: STRINGDB
C2CD4B
Tbio
Novelty: 0.12755154
Score: 0.473
Data Source: STRINGDB
PIK3IP1
Tbio
Family: Enzyme
Novelty: 0.07364653
Score: 0.465
Data Source: STRINGDB
SPAG4
Tbio
Novelty: 0.03721621
Score: 0.455
Data Source: STRINGDB
CIART
Tbio
Novelty: 0.09567981
Score: 0.449
Data Source: STRINGDB
PLIN2
Tbio
Novelty: 0.0020792
Score: 0.445
Data Source: STRINGDB
Publication Statistics
PubMed Score  33.68

PubMed score by year
PubTator Score  14.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer