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Tbio
TNPO3
Transportin-3

Protein Classes
Protein Summary
Description
Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains. The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Two transcript variants encoding different isoforms as well as a noncoding transcript have been found for this gene.[provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265388
  • ENSP00000265388
  • ENSG00000064419
  • ENST00000471234
  • ENSP00000418646

Symbol
  • IPO12
  • IPO12
  • TRNSR
  • LGMD1F
  • LGMDD2
  • MTR10A
  • TRN-SR
  • TRN-SR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
transcription factor binding site profile
0.9
trait
0.86
kinase perturbation
0.84
microRNA
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.12   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.12   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (159)
1 – 10 of 159
RSRP1
Tdark
Novelty: 1.02857143
p_int: 0.999878115
p_ni: 0.000121885
Score: 0.177
Data Source: BioPlex,STRINGDB
VSIG2
Tdark
Novelty: 0.71794872
p_int: 0.999700297
p_ni: 0.000299703
Data Source: BioPlex
STX5
Tbio
Novelty: 0.01314285
p_int: 0.999310181
p_ni: 0.000689819
Score: 0.234
Data Source: BioPlex,STRINGDB
CD70
Tbio
Novelty: 0.00552433
p_int: 0.996677497
p_ni: 0.003322503
Data Source: BioPlex
VIPR2
Tchem
Family: GPCR
Novelty: 0.00602252
p_int: 0.996548119
p_ni: 0.003451881
Data Source: BioPlex
CYB5B
Tbio
Novelty: 0.11412954
p_int: 0.996223715
p_ni: 0.003776285
Data Source: BioPlex
SCARA3
Tbio
Novelty: 0.00826861
p_int: 0.994096111
p_ni: 0.005903889
Data Source: BioPlex
SIGLECL1
Tdark
p_int: 0.986914252
p_ni: 0.013085748
Data Source: BioPlex
MICA
Tbio
Novelty: 0.00113138
p_int: 0.984827781
p_ni: 0.015172219
Data Source: BioPlex
P2RY12
Tclin
Family: GPCR
Novelty: 0.00057146
p_int: 0.980733954
p_ni: 0.019266046
Data Source: BioPlex
Publication Statistics
PubMed Score  58.12

PubMed score by year
PubTator Score  38.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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