You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ATP6V1D
V-type proton ATPase subunit D

Protein Summary
Description
Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain co ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216442
  • ENSP00000216442
  • ENSG00000100554
  • ENST00000554087
  • ENSP00000451167

Symbol
  • ATP6M
  • VATD
  • VATD
  • VMA8
  • ATP6M
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.99
transcription factor perturbation
0.98
interacting protein
0.96
virus perturbation
0.94


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.35   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.35   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V1 subunit D
VGNC:7643
452979
Macaque
ATPase H+ transporting V1 subunit D
710240
Mouse
MGI:1921084
73834
Rat
RGD:735119
299159
Dog
ATPase H+ transporting V1 subunit D
VGNC:38280
480360
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V1 subunit D
Macaque
ATPase H+ transporting V1 subunit D
Mouse
Rat
Dog
ATPase H+ transporting V1 subunit D
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y5K8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (22)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insulin receptor recycling
Reactome
Ion channel transport
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Insulin receptor recycling
Ion channel transport
Iron uptake and transport
Protein-Protein Interactions (211)
1 – 10 of 211
USP13
Tchem
Family: Enzyme
Novelty: 0.03470844
p_int: 0.999999988
p_ni: 9e-9
p_wrong: 3e-9
Data Source: BioPlex
ATP6V1E2
Tbio
Family: Enzyme
Novelty: 0.10447007
p_int: 0.999999937
p_ni: 6.3e-8
Score: 0.997
Data Source: BioPlex,STRINGDB
ATP6V1B1
Tchem
Family: Enzyme
Novelty: 0.01122589
p_int: 0.999999932
p_ni: 6.8e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
NCOA7
Tbio
Novelty: 0.08842763
p_int: 0.999999309
p_ni: 6.78e-7
p_wrong: 1.3e-8
Data Source: BioPlex
ATP6V1G2
Tbio
Family: Enzyme
Novelty: 0.10663259
p_int: 0.999998195
p_ni: 0.000001805
Score: 0.995
Data Source: BioPlex,STRINGDB
ATP6V1C1
Tbio
Family: Enzyme
Novelty: 0.03660846
p_int: 0.99999363
p_ni: 0.00000637
Score: 0.998
Data Source: BioPlex,STRINGDB
ATP6V1E1
Tbio
Family: Enzyme
Novelty: 0.04832113
p_int: 0.999986729
p_ni: 0.000013271
Score: 0.999
Data Source: BioPlex,STRINGDB
ANKRD13D
Tdark
Novelty: 2.14380936
p_int: 0.999970202
p_ni: 0.000029798
Data Source: BioPlex
ADD1
Tbio
Family: Enzyme
Novelty: 0.0040587
p_int: 0.999902574
p_ni: 0.000097426
Data Source: BioPlex
ATP6V0A2
Tbio
Family: Enzyme
Novelty: 0.00504614
p_int: 0.999889294
p_ni: 0.000110706
Score: 0.997
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  41.35

PubMed score by year
PubTator Score  3.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer