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Tbio
CD2AP
CD2-associated protein

Protein Summary
Description
Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 do ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359314
  • ENSP00000352264
  • ENSG00000198087

Symbol
  • CMS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.91
virus perturbation
0.76
drug perturbation
0.71
kinase perturbation
0.71
histone modification site profile
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.98   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.98   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
2
3
88.1
mean platelet volume
3
2
3
84.1
4
2
0
1.1
82.8
reticulocyte count
4
2
4
62.8
platelet count
2
2
2
56.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
88.1
mean platelet volume
3
84.1
0
1.1
82.8
reticulocyte count
4
62.8
platelet count
2
56.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD2 associated protein
VGNC:12763
472241
Macaque
CD2 associated protein
705221
Mouse
MGI:1330281
12488
Rat
RGD:727803
316258
Dog
CD2 associated protein
VGNC:38945
474928
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD2 associated protein
Macaque
CD2 associated protein
Mouse
Rat
Dog
CD2 associated protein
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y5K6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Cell-Cell communication (R-HSA-1500931)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell-Cell communication
Reactome
Nephrin family interactions
Name
Explore in Pharos
Explore in Source
Cell-Cell communication
Nephrin family interactions
Gene Ontology Terms (30)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (185)
1 – 10 of 185
SH3KBP1
Tbio
Family: Enzyme
Novelty: 0.01454593
p_int: 0.999974318
p_ni: 0.000025682
Score: 0.727
Data Source: BioPlex,STRINGDB
CAPZA2
Tbio
Novelty: 0.14014918
p_int: 0.999970167
p_ni: 0.000029833
Score: 0.498
Data Source: BioPlex,STRINGDB
STAP1
Tbio
Novelty: 0.17498048
p_int: 0.999923206
p_ni: 0.000076794
Score: 0.866
Data Source: BioPlex,STRINGDB
TCP10L
Tbio
Novelty: 0.24089479
p_int: 0.999274603
p_ni: 0.000725397
Data Source: BioPlex
ARHGAP44
Tbio
Family: Enzyme
Novelty: 0.11113234
p_int: 0.998904
p_ni: 0.001096
Score: 0.595
Data Source: BioPlex,STRINGDB
RACGAP1
Tbio
Family: Enzyme
Novelty: 0.01197099
p_int: 0.970634322
p_ni: 0.029365678
Score: 0.352
Data Source: BioPlex,STRINGDB
MRPL12
Tbio
Novelty: 0.10646542
p_int: 0.96578504
p_ni: 0.03421496
Data Source: BioPlex
TAS2R7
Tbio
Family: GPCR
Novelty: 0.10029148
p_int: 0.921709058
p_ni: 0.078290942
Score: 0.207
Data Source: BioPlex,STRINGDB
DACH2
Tbio
Novelty: 0.0806643
p_int: 0.911456081
p_ni: 0.088543919
Score: 0.241
Data Source: BioPlex,STRINGDB
SETX
Tbio
Family: Enzyme
Novelty: 0.00474094
p_int: 0.869762409
p_ni: 0.130237591
Score: 0.216
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  178.98

PubMed score by year
PubTator Score  89.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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