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Tbio
UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

Protein Summary
Description
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367448
  • ENSP00000356418
  • ENSG00000116750
  • ENST00000367449
  • ENSP00000356419
  • ENST00000367454
  • ENSP00000356424
  • ENST00000367455
  • ENSP00000356425

Symbol
  • UCH37
  • UCH37
  • CGI-70
  • INO80R
  • UCH-L5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.94
kinase perturbation
0.91
molecular function
0.9
biological process
0.86
histone modification site profile
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.98   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 296   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.98   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 296   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0