UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5
Protein Summary
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.
- ENST00000367448
- ENSP00000356418
- ENSG00000116750
- ENST00000367449
- ENSP00000356419
- ENST00000367454
- ENSP00000356424
- ENST00000367455
- ENSP00000356425
- UCH37
- UCH37
- CGI-70
- INO80R
- UCH-L5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.94 | ||
kinase perturbation | 0.91 | ||
molecular function | 0.9 | ||
biological process | 0.86 | ||
histone modification site profile | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 85.98 (req: < 5)
Gene RIFs: 38 (req: <= 3)
Antibodies: 296 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 85.98 (req: >= 5)
Gene RIFs: 38 (req: > 3)
Antibodies: 296 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0