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Tbio
UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

Protein Summary
Description
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367448
  • ENSP00000356418
  • ENSG00000116750
  • ENST00000367449
  • ENSP00000356419
  • ENST00000367454
  • ENSP00000356424
  • ENST00000367455
  • ENSP00000356425

Symbol
  • UCH37
  • UCH37
  • CGI-70
  • INO80R
  • UCH-L5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.94
kinase perturbation
0.91
molecular function
0.9
biological process
0.86
histone modification site profile
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.89   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 296   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.89   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 296   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Downregulation of TGF-beta receptor signaling
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Deubiquitination
Downregulation of TGF-beta receptor signaling
Metabolism of proteins
Post-translational protein modification
Signal Transduction
Protein-Protein Interactions (238)
1 – 10 of 238
ADRM1
Tbio
Novelty: 0.01545209
p_int: 0.999999778
p_ni: 2.22e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
INO80E
Tdark
Novelty: 0.38735443
p_int: 0.999999743
p_ni: 2.56e-7
p_wrong: 1e-9
Score: 0.967
Data Source: BioPlex,STRINGDB
ACTR8
Tbio
Novelty: 0.12366847
p_int: 0.999999468
p_ni: 5.32e-7
Score: 0.959
Data Source: BioPlex,STRINGDB
INO80B
Tbio
Novelty: 0.02405051
p_int: 0.999999343
p_ni: 6.57e-7
Score: 0.981
Data Source: BioPlex,STRINGDB
ACTR5
Tbio
Novelty: 0.15502033
p_int: 0.999999132
p_ni: 8.68e-7
Score: 0.957
Data Source: BioPlex,STRINGDB
NFRKB
Tbio
Novelty: 0.13445983
p_int: 0.999999082
p_ni: 9.18e-7
Score: 0.997
Data Source: BioPlex,STRINGDB
TFPT
Tbio
Novelty: 0.08573384
p_int: 0.999995136
p_ni: 0.000003847
p_wrong: 0.000001017
Score: 0.95
Data Source: BioPlex,STRINGDB
RGPD8
Tdark
Novelty: 0.12397737
p_int: 0.999817143
p_ni: 0.000182857
Score: 0.196
Data Source: BioPlex,STRINGDB
YY1
Tbio
Family: TF
Novelty: 0.00120891
p_int: 0.999649159
p_ni: 0.00035083
p_wrong: 1.1e-8
Score: 0.959
Data Source: BioPlex,STRINGDB
TMEM31
Tdark
Novelty: 0.65381391
p_int: 0.999409042
p_ni: 0.000590958
Data Source: BioPlex
Publication Statistics
PubMed Score  75.89

PubMed score by year
PubTator Score  49.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer