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Tchem
KLK4
Kallikrein-4

Protein Classes
Protein Summary
Description
Has a major role in enamel formation (PubMed:15235027). Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity). Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Several transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000431178
  • ENSP00000399448
  • ENSG00000167749

Symbol
  • EMSP1
  • PRSS17
  • PSTS
  • ARM1
  • EMSP
  • PSTS
  • AI2A1
  • EMSP1
  • KLK-L1
  • PRSS17
  • kallikrein
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.78
cell type or tissue
0.65
protein domain
0.58
biological term
0.54
cell line
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4640.66   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4640.66   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (2)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Name
Explore in Pharos
Explore in Source
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Protein-Protein Interactions (92)
1 – 10 of 92
HLA-DRA
Tbio
Novelty: 0.00705028
p_int: 0.999486575
p_ni: 0.000016976
p_wrong: 0.000496449
Score: 0.806
Data Source: BioPlex,STRINGDB
KCNIP4
Tbio
Family: IC
Novelty: 0.01754679
p_int: 0.801663715
p_ni: 0.19833593
p_wrong: 3.55e-7
Score: 0.855
Data Source: BioPlex,STRINGDB
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00096649
Score: 0.946
Data Source: STRINGDB
KNG1
Tchem
Novelty: 0.00008572
Score: 0.922
Data Source: STRINGDB
SERPING1
Tbio
Family: Enzyme
Novelty: 0.00076515
Score: 0.865
Data Source: STRINGDB
MMP20
Tbio
Family: Enzyme
Novelty: 0.01173195
Score: 0.844
Data Source: STRINGDB
ENAM
Tbio
Novelty: 0.00705934
Score: 0.841
Data Source: STRINGDB
REN
Tclin
Family: Enzyme
Novelty: 0.00002857
Score: 0.838
Data Source: STRINGDB
AMBN
Tbio
Novelty: 0.00438592
Score: 0.814
Data Source: STRINGDB
AMELX
Tbio
Novelty: 0.0005058
Score: 0.803
Data Source: STRINGDB
Publication Statistics
PubMed Score  4640.66

PubMed score by year
PubTator Score  1420.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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