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Tbio
SPO11
Meiotic recombination protein SPO11

Protein Summary
Description
Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2. Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them ha ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345868
  • ENSP00000316034
  • ENSG00000054796
  • ENST00000371263
  • ENSP00000360310

Symbol
  • CT35
  • TOPVIA
  • SPATA43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
protein domain
0.73
cellular component
0.64
biological process
0.59
gene perturbation
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 374.58   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 374.58   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
8
13
98.4
mean reticulocyte volume
1
4
4
98.3
mean corpuscular volume
4
4
5
98.1
reticulocyte measurement
3
6
8
97.8
mean platelet volume
3
3
4
91.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
13
98.4
mean reticulocyte volume
4
98.3
mean corpuscular volume
5
98.1
reticulocyte measurement
8
97.8
mean platelet volume
4
91.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SPO11, initiator of meiotic double stranded breaks
VGNC:10268
458358
Mouse
MGI:1349669
26972
Rat
RGD:1306454
366261
Dog
SPO11, initiator of meiotic double stranded breaks
VGNC:46750
610247
Horse
SPO11, initiator of meiotic double stranded breaks
VGNC:23528
100050365
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SPO11, initiator of meiotic double stranded breaks
Mouse
Rat
Dog
SPO11, initiator of meiotic double stranded breaks
Horse
SPO11, initiator of meiotic double stranded breaks
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y5K1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Meiosis
Reactome
Meiotic recombination
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Cell Cycle
Meiosis
Meiotic recombination
Reproduction
Gene Ontology Terms (21)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (239)
1 – 10 of 239
RAD51
Tchem
Novelty:  0.00011516
Score:  0.993
Data Source:  STRINGDB
ATM
Tchem
Family:  Kinase
Novelty:  0.00019169
Score:  0.987
Data Source:  STRINGDB
DMC1
Tbio
Novelty:  0.05445277
Score:  0.987
Data Source:  STRINGDB
RAD50
Tbio
Novelty:  0.02161298
Score:  0.985
Data Source:  STRINGDB
MRE11
Tbio
Novelty:  0.01038348
Score:  0.983
Data Source:  STRINGDB
PRDM9
Tbio
Family:  TF; Epigenetic
Novelty:  0.0051717
Score:  0.976
Data Source:  STRINGDB
RBBP8
Tbio
Family:  Enzyme
Novelty:  0.0044233
Score:  0.963
Data Source:  STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
Score:  0.961
Data Source:  STRINGDB
BRCA1
Tchem
Novelty:  0.00011146
Score:  0.952
Data Source:  STRINGDB
MUS81
Tbio
Family:  Enzyme
Novelty:  0.00532122
Score:  0.952
Data Source:  STRINGDB
Publication Statistics
PubMed Score  374.58

PubMed score by year
PubTator Score  37.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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