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Tbio
TIMM8B
Mitochondrial import inner membrane translocase subunit Tim8 B

Protein Summary
Description
Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000504148
  • ENSP00000422122
  • ENSG00000150779

Symbol
  • DDP2
  • DDPL
  • TIM8B
  • DDP2
  • TIM8B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
virus perturbation
0.98
kinase perturbation
0.96
histone modification site profile
0.93
transcription factor binding site profile
0.9


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.77   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.77   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
PDYN
Tbio
Novelty:  0.00039564
p_int:  0.994811707
p_ni:  0.005188292
p_wrong:  1e-9
Score:  0.54
Data Source:  BioPlex,STRINGDB
ANKRD9
Tdark
Novelty:  0.43181793
p_int:  0.960345171
p_ni:  0.039654829
Data Source:  BioPlex
YBEY
Tdark
Family:  Enzyme
Novelty:  0.02778029
p_int:  0.943556767
p_ni:  0.056443232
Score:  0.158
Data Source:  BioPlex,STRINGDB
ZNF385C
Tdark
Novelty:  2.23931637
p_int:  0.917248842
p_ni:  0.082751158
Data Source:  BioPlex
TIMM13
Tdark
Family:  Enzyme
Novelty:  0.04802297
Score:  0.999
Data Source:  Reactome,STRINGDB
TIMM9
Tbio
Family:  Enzyme
Novelty:  0.02996764
Score:  0.989
Data Source:  STRINGDB
TIMM10
Tbio
Family:  Enzyme
Novelty:  0.02727463
Score:  0.974
Data Source:  STRINGDB
TIMM23
Tbio
Family:  Enzyme
Novelty:  0.06463808
Score:  0.972
Data Source:  STRINGDB
CHCHD4
Tbio
Novelty:  0.01204944
Score:  0.969
Data Source:  STRINGDB
TIMM22
Tbio
Family:  Enzyme
Novelty:  0.12627933
Score:  0.966
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Mitochondrial protein import (R-HSA-1268020)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 18 measurement
1
1
1
87.5
waist-hip ratio
2
2
2
83
blood protein measurement
1
1
1
80.8
smoking status measurement
2
2
2
68.1
smoking initiation
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 18 measurement
1
87.5
waist-hip ratio
2
83
blood protein measurement
1
80.8
smoking status measurement
2
68.1
smoking initiation
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
mitochondrial import inner membrane translocase subunit Tim8 B
715327
Mouse
MGI:1353424
30057
Rat
RGD:619840
64372
Dog
translocase of inner mitochondrial membrane 8 homolog B
VGNC:49624
611348
Horse
translocase of inner mitochondrial membrane 8 homolog B
VGNC:50509
100062094
Species
Name
OMA
EggNOG
Inparanoid
Macaque
mitochondrial import inner membrane translocase subunit Tim8 B
Mouse
Rat
Dog
translocase of inner mitochondrial membrane 8 homolog B
Horse
translocase of inner mitochondrial membrane 8 homolog B
Publication Statistics
PubMed Score 34.77
PubMed score by year
PubTator Score 9.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title