Tbio TIMM9 Mitochondrial import inner membrane translocase subunit Tim9

Protein Summary

Description

Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. TIMM9 belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM, Apr 2004]

Uniprot Accession IDs

• Q9Y5J7
• B2R584

Gene Name

• TIMM9

Ensembl ID

• ENST00000395159
• ENSP00000378588
• ENSG00000100575
• ENST00000555061
• ENSP00000450638
• ENST00000555404
• ENSP00000451198
• ENST00000555593
• ENSP00000451006

Symbol

• TIM9
• TIM9A
• TIMM9A
• TIM9
• TIM9A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
disease perturbation	0.9
transcription factor binding site profile	0.88
gene perturbation	0.78
virus perturbation	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.31   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 105   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.31   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0