You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
TIMM10B
Mitochondrial import inner membrane translocase subunit Tim10 B

Protein Classes
Protein Summary
Description
Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space. FXC1, or TIMM10B, belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254616
  • ENSP00000254616
  • ENSG00000132286
  • ENST00000533379
  • ENSP00000436948

Symbol
  • FXC1
  • TIM9B
  • TIMM9B
  • FXC1
  • Tim9b
  • TIM10B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
cell type or tissue
0.83
histone modification site profile
0.75
transcription factor perturbation
0.74
transcription factor binding site profile
0.67


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.21   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.21   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
translocase of inner mitochondrial membrane 10B
VGNC:53176
747415
Macaque
translocase of inner mitochondrial membrane 10B
711085
Mouse
MGI:1315196
14356
Rat
RGD:71097
84384
Dog
translocase of inner mitochondrial membrane 10B
VGNC:52855
610986
Species
Name
OMA
EggNOG
Inparanoid
Chimp
translocase of inner mitochondrial membrane 10B
Macaque
translocase of inner mitochondrial membrane 10B
Mouse
Rat
Dog
translocase of inner mitochondrial membrane 10B
Pathways (2)
Mitochondrial protein import (R-HSA-1268020)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (74)
1 – 10 of 74
AGK
Tbio
Family: Enzyme
Novelty: 0.00919083
p_int: 0.999999962
p_ni: 1.6e-8
p_wrong: 2.2e-8
Score: 0.927
Data Source: BioPlex,STRINGDB
TIMM10
Tbio
Family: Enzyme
Novelty: 0.02727463
p_int: 0.999999949
p_ni: 2e-9
p_wrong: 4.9e-8
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
ADCYAP1
Tbio
Family: Enzyme
Novelty: 0.00080219
p_int: 0.999385906
p_ni: 0.000011052
p_wrong: 0.000603043
Score: 0.235
Data Source: BioPlex,STRINGDB
PRKCE
Tchem
Family: Kinase
Novelty: 0.00890161
p_int: 0.999207637
p_ni: 0.000786403
p_wrong: 0.00000596
Data Source: BioPlex
ATP6V1D
Tbio
Family: Enzyme
Novelty: 0.02298626
p_int: 0.997033696
p_ni: 0.000164772
p_wrong: 0.002801532
Data Source: BioPlex
MSI2
Tbio
Novelty: 0.01716735
p_int: 0.996703775
p_ni: 0.000001199
p_wrong: 0.003295026
Score: 0.529
Data Source: BioPlex,STRINGDB
HPSE2
Tbio
Family: Enzyme
Novelty: 0.00583615
p_int: 0.99655752
p_ni: 0.003436323
p_wrong: 0.000006158
Data Source: BioPlex
PNOC
Tbio
Novelty: 0.00132014
p_int: 0.934621629
p_ni: 0.001700624
p_wrong: 0.063677747
Data Source: BioPlex
TIMM22
Tbio
Family: Enzyme
Novelty: 0.12627933
Score: 0.985
Data Source: Reactome,STRINGDB
TIMM23
Tbio
Family: Enzyme
Novelty: 0.06463808
Score: 0.968
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.21

PubMed score by year
PubTator Score  0.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer