Tdark TIMM10B Mitochondrial import inner membrane translocase subunit Tim10 B

Protein Summary

Description

Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space. FXC1, or TIMM10B, belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM, Apr 2004]

Uniprot Accession IDs

• Q9Y5J6
• Q96FF3

Gene Name

• TIMM10B

Ensembl ID

• ENST00000254616
• ENSP00000254616
• ENSG00000132286
• ENST00000533379
• ENSP00000436948

Symbol

• FXC1
• TIM9B
• TIMM9B
• FXC1
• Tim9b
• TIM10B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
cell type or tissue	0.83
histone modification site profile	0.75
transcription factor perturbation	0.74
transcription factor binding site profile	0.67

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Mitochondrial Import Inner Membrane Translocase Subunit Tim10 B

Protein / Membrane Traffic Protein / Mitochondrial Import Inner Membrane Translocase Subunit Tim10 B

DTO Classes

Protein / Transporter / Mitochondrial Import Inner Membrane Translocase Subunit Tim10 B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.42   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 92   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.42   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0