Tbio PHLDA3 Pleckstrin homology-like domain family A member 3

Protein Summary

Description

p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.

Uniprot Accession IDs

• Q9Y5J5
• B2R5A4
• Q53HD6
• Q8NBW9

Gene Name

• PHLDA3

Ensembl ID

• ENST00000367309
• ENSP00000356278
• ENSG00000174307
• ENST00000367311
• ENSP00000356280

Symbol

• TIH1
• TIH1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
disease perturbation	0.87
interacting protein	0.77
PubMedID	0.75
transcription factor binding site profile	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.81   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.81   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0