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Tbio
HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

Protein Summary
Description
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337919
  • ENSP00000338272
  • ENSG00000164683
  • ENST00000354724
  • ENSP00000346761

Symbol
  • BHLHB31
  • CHF2
  • HERP2
  • HESR1
  • HRT1
  • CHF2
  • OAF1
  • HERP2
  • HESR1
  • HRT-1
  • NERP2
  • hHRT1
  • BHLHb31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
biological process
0.99
PubMedID
0.84
transcription factor perturbation
0.84
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.12   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 383   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.12   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 383   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (136)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Disease
Diseases of signal transduction
Gene expression (Transcription)
Gene Ontology Terms (42)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (132)
1 – 10 of 132
HEY2
Tbio
Family: TF
Novelty: 0.00569776
p_int: 1
Score: 0.971
Data Source: BioPlex,STRINGDB
TLE1
Tbio
Novelty: 0.00594261
p_int: 0.999999696
p_ni: 1.81e-7
p_wrong: 1.23e-7
Score: 0.648
Data Source: BioPlex,STRINGDB
NOTCH1
Tchem
Novelty: 0.00012547
Score: 0.994
Data Source: STRINGDB
RBPJ
Tbio
Family: TF
Novelty: 0.00168834
Score: 0.98
Data Source: STRINGDB
NOTCH3
Tchem
Novelty: 0.000953
Score: 0.979
Data Source: STRINGDB
NOTCH4
Tchem
Novelty: 0.00471643
Score: 0.977
Data Source: STRINGDB
MYOD1
Tbio
Family: TF
Novelty: 0.00053412
Score: 0.968
Data Source: STRINGDB
GATA1
Tbio
Family: TF
Novelty: 0.00077901
Score: 0.957
Data Source: STRINGDB
MAML1
Tbio
Novelty: 0.01302751
Score: 0.954
Data Source: STRINGDB
HES1
Tbio
Family: TF
Novelty: 0.00974115
Score: 0.95
Data Source: STRINGDB
Publication Statistics
PubMed Score  188.12

PubMed score by year
PubTator Score  190.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer