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Tdark
UTP18
U3 small nucleolar RNA-associated protein 18 homolog

Protein Summary
Description
Involved in nucleolar processing of pre-18S ribosomal RNA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225298
  • ENSP00000225298
  • ENSG00000011260

Symbol
  • WDR50
  • WDR50
  • CGI-48
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
cell type or tissue
0.96
drug perturbation
0.96
transcription factor binding site profile
0.9
histone modification site profile
0.89


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.68   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.68   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (345)
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.999859374
p_ni:  0.000140626
Score:  0.3
Data Source:  BioPlex,STRINGDB
MPHOSPH6
Tbio
Family:  Enzyme
Novelty:  0.24387167
p_int:  0.992414469
p_ni:  0.007585531
Score:  0.923
Data Source:  BioPlex,STRINGDB
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.969705966
p_ni:  0.030294034
Score:  0.443
Data Source:  BioPlex,STRINGDB
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.933111104
p_ni:  0.066888896
Score:  0.364
Data Source:  BioPlex,STRINGDB
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.873575712
p_ni:  0.126424288
Score:  0.185
Data Source:  BioPlex,STRINGDB
CCT5
Tbio
Novelty:  0.02369118
p_int:  0.771934553
p_ni:  0.228065446
Score:  0.367
Data Source:  BioPlex,STRINGDB
WDR75
Tbio
Novelty:  0.09443914
Score:  0.999
Data Source:  STRINGDB
WDR46
Tbio
Novelty:  0.19307408
Score:  0.999
Data Source:  STRINGDB
MPHOSPH10
Tbio
Novelty:  0.04846226
Score:  0.999
Data Source:  STRINGDB
NOP14
Tbio
Novelty:  0.08903014
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
17.8
1
1
1
15.8
BMI-adjusted hip circumference
1
1
1
4.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
17.8
1
15.8
BMI-adjusted hip circumference
1
4.3
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
UTP18, small subunit processome component
708052
Mouse
MGI:1923402
217109
Rat
RGD:1309957
303456
Dog
UTP18, small subunit processome component
VGNC:48210
491088
Horse
UTP18, small subunit processome component
VGNC:24861
100070268
Species
Name
OMA
EggNOG
Inparanoid
Macaque
UTP18, small subunit processome component
Mouse
Rat
Dog
UTP18, small subunit processome component
Horse
UTP18, small subunit processome component
Publication Statistics
PubMed Score 4.68
PubMed score by year
PubTator Score 1.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title