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Tdark
PCDHGA9
Protocadherin gamma-A9

Protein Summary
Description
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000573521
  • ENSP00000460274
  • ENSG00000261934
  • ENST00000616887
  • ENSP00000480862

Symbol
  • PCDH-GAMMA-A9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
cell type or tissue
0.58
protein domain
0.58
microRNA
0.5
tissue sample
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.79   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.79   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (11)
PCDHGA5
Tdark
Novelty:  2.13631603
p_int:  1
Score:  0.176
Data Source:  BioPlex,STRINGDB
PCDHGB1
Tdark
Novelty:  0.60440805
p_int:  0.999978336
p_ni:  0.00002139
p_wrong:  2.75e-7
Score:  0.246
Data Source:  BioPlex,STRINGDB
PRAMEF19
Tdark
Novelty:  3.33845237
Score:  0.514
Data Source:  STRINGDB
CEACAM20
Tdark
Novelty:  0.43514672
Score:  0.473
Data Source:  STRINGDB
SMAGP
Tbio
Novelty:  0.2379422
Score:  0.473
Data Source:  STRINGDB
CNTNAP3B
Tdark
Novelty:  0.25889644
Score:  0.452
Data Source:  STRINGDB
CNNM1
Tdark
Novelty:  0.11053515
Score:  0.44
Data Source:  STRINGDB
BOLA2
Tbio
Novelty:  0.18144236
Score:  0.426
Data Source:  STRINGDB
COLGALT2
Tbio
Family:  Enzyme
Novelty:  0.15981994
Score:  0.42
Data Source:  STRINGDB
CMTM4
Tbio
Novelty:  0.09490151
Score:  0.42
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
4
6
93.5
self reported educational attainment
2
2
2
57.1
triglyceride measurement
1
1
1
47.7
1
1
0
1
46.5
age at first birth measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
6
93.5
self reported educational attainment
2
57.1
triglyceride measurement
1
47.7
0
1
46.5
age at first birth measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Anole lizard
protocadherin gamma-A10-like
100553507
Species
Name
OMA
EggNOG
Inparanoid
Anole lizard
protocadherin gamma-A10-like
Publication Statistics
PubMed Score 1.79
PubMed score by year
PubTator Score 0.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title