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Tdark
PCDHB11
Protocadherin beta-11

Protein Summary
Description
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354757
  • ENSP00000346802
  • ENSG00000197479
  • ENST00000624887
  • ENSP00000485553

Symbol
  • ME2
  • PCDH-BETA11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.94
cell type or tissue
0.76
microRNA
0.65
PubMedID
0.62
protein domain
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.33   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.33   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protocadherin beta 11
737812
Pig
protocadherin beta-11-like
100737316
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protocadherin beta 11
Pig
protocadherin beta-11-like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y5F2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (54)
1 – 10 of 54
PCDHB13
Tdark
Novelty: 1.09097405
p_int: 1
Score: 0.267
Data Source: BioPlex,STRINGDB
PCDHB12
Tdark
Novelty: 3.05455067
p_int: 1
Score: 0.237
Data Source: BioPlex,STRINGDB
TMTC2
Tbio
Novelty: 0.17232458
p_int: 0.999999095
p_ni: 6.07e-7
p_wrong: 2.98e-7
Score: 0.248
Data Source: BioPlex,STRINGDB
SPECC1
Tbio
Novelty: 0.00830299
p_int: 0.999890174
p_ni: 0.000109741
p_wrong: 8.5e-8
Score: 0.197
Data Source: BioPlex,STRINGDB
LTBP1
Tbio
Novelty: 0.00958396
p_int: 0.999522549
p_ni: 0.00047745
p_wrong: 1e-9
Score: 0.159
Data Source: BioPlex,STRINGDB
RPL23
Tbio
Novelty: 0.02741113
p_int: 0.999450563
p_ni: 0.000549437
Data Source: BioPlex
VWA1
Tbio
Novelty: 0.00212445
p_int: 0.998965965
p_ni: 0.00103401
p_wrong: 2.5e-8
Score: 0.15
Data Source: BioPlex,STRINGDB
DCBLD2
Tbio
Novelty: 0.06514947
p_int: 0.998962054
p_ni: 0.001037926
p_wrong: 2e-8
Data Source: BioPlex
HLA-A
Tbio
Novelty: 0.00270731
p_int: 0.998735239
p_ni: 0.001264761
Data Source: BioPlex
ST7L
Tbio
Novelty: 0.03661324
p_int: 0.99728934
p_ni: 0.002710566
p_wrong: 9.4e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  1.33

PubMed score by year
PubTator Score  1.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer