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Tdark
PCDHB5
Protocadherin beta-5

Protein Summary
Description
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231134
  • ENSP00000231134
  • ENSG00000113209

Symbol
  • PCDH-BETA5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.63
gene perturbation
0.59
protein domain
0.58
cell line
0.5
tissue
0.49


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.36   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.36   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y5E4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (18)
1 – 10 of 18
PCDHB3
Tdark
Novelty: 0.51391546
p_int: 0.999999995
p_wrong: 5e-9
Score: 0.22
Data Source: BioPlex,STRINGDB
TNFAIP3
Tbio
Novelty: 0.00257088
p_int: 0.999793723
p_ni: 0.000206217
p_wrong: 6e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
PTP4A2
Tchem
Family: Enzyme
Novelty: 0.0083639
p_int: 0.96824698
p_ni: 0.03171686
p_wrong: 0.00003616
Score: 0.188
Data Source: BioPlex,STRINGDB
ATP2A3
Tbio
Family: Transporter
Novelty: 0.0090982
p_int: 0.965579229
p_ni: 0.034420771
Data Source: BioPlex
RDH13
Tbio
Family: Enzyme
Novelty: 0.20184998
p_int: 0.912845357
p_ni: 0.087154643
Score: 0.189
Data Source: BioPlex,STRINGDB
RPL23
Tbio
Novelty: 0.02741113
p_int: 0.910563965
p_ni: 0.089436035
Data Source: BioPlex
GAS6
Tbio
Novelty: 0.00297606
p_int: 0.847319207
p_ni: 0.152657985
p_wrong: 0.000022808
Score: 0.163
Data Source: BioPlex,STRINGDB
CLDN9
Tbio
Novelty: 0.06435094
Score: 0.629
Data Source: STRINGDB
CLDN6
Tbio
Novelty: 0.01814018
Score: 0.601
Data Source: STRINGDB
CDCA7L
Tbio
Novelty: 0.04191594
Score: 0.525
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.36

PubMed score by year
PubTator Score  0.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer